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We conducted a meta\u2010analysis of 35 studies from 11 LAC countries, encompassing 3206 patients with AD and 5515 controls. The \u03b54 allele demonstrated significant association with increased AD risk (odds ratio [OR]\u00a0=\u00a03.25, 95% confidence interval [2.82\u20133.76]), while \u03b53 showed lower odds (0.42, [0.37\u20130.48]). Homozygous \u03b54\/\u03b54 carriers had elevated risk (6.84, [5.09\u20139.19]), and heterozygous \u03b53\/\u03b54 carriers showed moderate risk (2.59, [2.31\u20132.91]). Country\u2010level analyses revealed variability, with Ecuador showing the highest OR for \u03b54\/\u03b54 (13.29, [1.56\u2013113.4]). These results confirm\n                    <jats:italic>APOE<\/jats:italic>\n                    \u03b54 as a major AD risk factor in LAC populations and highlight regional differences relevant to precision medicine.\n                  <\/jats:p>","DOI":"10.1002\/alz.71224","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T03:06:36Z","timestamp":1771815996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of apolipoprotein E variants on Alzheimer's disease in Latin America: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"22","author":[{"given":"Paulina","family":"Orellana","sequence":"first","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat) Universidad Adolfo Ibanez  Santiago 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