{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:40:24Z","timestamp":1790606424804,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Clarifying relationships between amyloid, tau, and cognition is crucial to understanding dementia risk, but has been mainly performed in non\u2010Hispanic White (NHW) participants. It is unknown whether findings are generalizable to other ethnoracial groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We evaluated relationships between amyloid\u2010\u03b2 (A\u03b2) positivity, apolipoprotein E allele (\n                      <jats:italic>APOE)<\/jats:italic>\n                      \u03b54, tau\u2010positron emission tomography (PET)\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010PI\u20102620, and cognitive performance in 1181 cognitively unimpaired (451 NHW, 353 Hispanic, and 377 Black) and 383 mild cognitively impaired (85 NHW, 129 Hispanic, and 169 Black) participants from the Health and Aging Brain Study\u2010Health Disparities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Black (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.28,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and Hispanic (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) participants had higher medial temporal lobe (MTL) tau than NHW participants; however, findings were attenuated when accounting for choroid plexus off\u2010target binding. Hispanic participants showed higher tau in lateral temporal regions compared to NHW and Black participants; however, reducing meningeal off\u2010target binding through erosion demonstrated similar lateral temporal tau across groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Factors other than amyloid and tau may impact cognition in Black participants. PI2620 off\u2010target ethnoracial differences should be investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71226","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:29:29Z","timestamp":1773030569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The relationships between ethnoracial identity, A\u03b2 positivity,\n                    <i>APOE<\/i>\n                    \u03b54, and medial temporal lobe tau PET"],"prefix":"10.1002","volume":"22","author":[{"given":"Koral V.","family":"Wheeler","sequence":"first","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria R.","family":"Tennant","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens 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