{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:12Z","timestamp":1786976832801,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019889","name":"Weston Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019889","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000143","name":"Alzheimer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014900","name":"Sleep Research Society Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Since sleep disturbance is a modifiable risk factor for Alzheimer's disease (AD), we tested associations between sleep and AD pathology in cognitively unimpaired (CU) persons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We included 223 participants from the PREVENT\u2010AD cohort with self\u2010reported measures of sleep, objective actigraphy measures of sleep, and positron emission tomography (PET) scans for AD pathology quantification. Repeated PET scans (mean follow\u2010up: 4.31\u00a0\u00b1\u00a00.55\u00a0years) were available for 103 participants. We conducted robust linear models (RLM) for cross\u2010sectional analyses and RLMs using the annual change in AD pathology for longitudinal analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      All actigraphy\u2010based sleep variability measures were associated with tau burden (duration:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.121 [95% confidence interval {CI}\u00a0=\u00a00.010;\u00a00.232],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.034; efficiency: 0.122 [0.010;\u00a00.235], 0.033; fragmentation: 0.115 [0.010;\u00a00.221], 0.033). Greater variability in sleep fragmentation was also associated with amyloid burden (0.074 [0.008;\u00a00.140], 0.028), and variability in sleep efficiency portended amyloid burden and faster accumulation over time (0.075 [0.009;\u00a00.141], 0.026; 0.164 [0.008;\u00a00.320], 0.039; respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Irregularity in sleep patterns is associated with higher pathological burden and faster amyloid accumulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71228","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:43:03Z","timestamp":1773135783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal association between sleep and Alzheimer's pathology"],"prefix":"10.1002","volume":"22","author":[{"given":"Bery","family":"Mohammediyan","sequence":"first","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine Research Center of the CIUSSS\u2010NIM  Montreal Quebec Canada"},{"name":"Department of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9e\u2010Ann","family":"Baril","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine Research Center of the CIUSSS\u2010NIM  Montreal Quebec Canada"},{"name":"Department of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Fajardo Valdez","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"St\u2010Onge","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Pichet Binette","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l'Institut Universitaire de G\u00e9riatrie de Montr\u00e9al  Montr\u00e9al Quebec Canada"},{"name":"Department of Physiology and Pharmacology Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Quebec Canada"},{"name":"Clinical Memory Research Unit Department of Clinical Sciences Malm\u00f6 Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Carrier","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine Research Center of the CIUSSS\u2010NIM  Montreal Quebec Canada"},{"name":"Department of Psychology University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiya R.","family":"Geddes","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute  Montreal Quebec Canada"},{"name":"Department of Psychiatry Faculty of Medicine McGill University  Montreal Quebec Canada"},{"name":"Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Ducharme","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute  Montreal Quebec Canada"},{"name":"McConnell Brain Imaging Centre Montreal Neurological Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Montembeault","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute  Montreal Quebec Canada"},{"name":"Department of Psychiatry Faculty of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Soucy","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre Montreal Neurological Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Breitner","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute  Montreal Quebec Canada"},{"name":"Department of Psychiatry Faculty of Medicine McGill University  Montreal Quebec Canada"},{"name":"McConnell Brain Imaging Centre Montreal Neurological Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judes","family":"Poirier","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute  Montreal Quebec Canada"},{"name":"Department of Psychiatry Faculty of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Villeneuve","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute  Montreal Quebec Canada"},{"name":"Department of Psychiatry Faculty of Medicine McGill University  Montreal Quebec Canada"},{"name":"McConnell Brain Imaging Centre Montreal Neurological Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the PREVENT\u2010AD Research 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