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We investigated spatial relationships among microglial activation, neuronal health, and amyloid beta (A\u03b2) in the AD spectrum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Forty healthy controls, 37 patients with mild cognitive impairment (MCI), and 62 patients with AD underwent whole\u2010brain high\u2010resolution\n                      <jats:sup>1<\/jats:sup>\n                      H\u2010magnetic resonance spectroscopic imaging (MRSI), [\n                      <jats:sup>1<\/jats:sup>\n                      <jats:sup>8<\/jats:sup>\n                      F]DPA\u2010714, and [\n                      <jats:sup>1<\/jats:sup>\n                      <jats:sup>8<\/jats:sup>\n                      F]AV\u201045 positron emission tomography (PET). Regional and voxel\u2010wise analyses assessed changes and associations of microglial activation with N\u2010acetylaspartate (NAA) and A\u03b2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>MCI and AD patients showed higher microglial activation and lower NAA, correlating with cognitive decline. In controls and MCI, microglial activation correlated positively with NAA and A\u03b2 in early amyloid\u2010accumulating regions. Conversely, negative correlations with NAA emerged in the hippocampus in MCI and extended to temporal and occipital regions in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      For the first time, we identified two distinct spatial association patterns between [\n                      <jats:sup>1<\/jats:sup>\n                      <jats:sup>8<\/jats:sup>\n                      F]DPA\u2010714 PET and NAA, shedding light on the complex interplay between neuroinflammation and neuronal health in AD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71229","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:08:35Z","timestamp":1772989715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual association patterns 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