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A matched Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort served as comparator. Cognitive tests, plasma biomarkers, and optional amyloid\/tau positron emission tomography (PET) were assessed over 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Lecanemab significantly attenuated cognitive decline versus ADNI. Plasma A\u03b242, A\u03b240, phosphorylated tau 217 (p\u2011tau217), glial fibrillary acidic protein (GFAP), and ratios showed robust changes; a p\u2011tau217 reduction correlated with amyloid PET clearance (mean \u221222.1\u00a0Centiloid; 29.2% turned amyloid\u2010negative). Apolipoprotein E\n                      <jats:italic>(<\/jats:italic>\n                      <jats:italic>APOE)<\/jats:italic>\n                      \u03b54\u00a0non\u2010carriers showed greater improvements. Infusion reactions occurred in 11.1% and amyloid\u2010related imaging abnormalities in 9.2% (1.6% symptomatic), with no stage\u2010related safety differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Lecanemab was effective and well tolerated in real\u2010world Chinese patients. Plasma p\u2011tau217 may serve as a sensitive, minimally invasive treatment\u2010response biomarker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71231","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:00:33Z","timestamp":1773399633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effectiveness, safety, and biomarker dynamics of lecanemab in Chinese Alzheimer's disease population: a multicenter real\u2010world study"],"prefix":"10.1002","volume":"22","author":[{"given":"Wang","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Neurology Institute of Neuroscience, the Second Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Neuroscience, the Second Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Neuroscience, the Second Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Neuroscience, the Second Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Neurology Shenzhen People's Hospital (First Affiliated Hospital of Southern University of Science and Technology), Second Clinical College, Jinan University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqun","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology Foshan Hospital of Sun Yat\u2010Sen University  Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haobo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Guangzhou First People's Hospital South China University of Technology  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Zhujiang Hospital Southern Medical University  Guangzhou Guangdong P.R. 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