{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:26Z","timestamp":1783322186091,"version":"3.54.6"},"reference-count":122,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010232","name":"National Institute of Development Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["Provided in the ms"],"award-info":[{"award-number":["Provided in the ms"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Frailty influences dementia risk and severity. However, its role in differentiating dementia subtypes and associations with brain structural and functional alterations remain understudied, especially in Latin America.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Multi\u2010Partner Consortium to Expand Dementia Research in Latin America data included 3461 participants (cognitively unimpaired [CU], Alzheimer's disease [AD], and frontotemporal lobar degeneration [FTLD]) from Latin America using a frailty index constructed from 32 health\u2010related variables. XGBoost\u2010logistic regression models tested group discrimination, and voxel\u2010based morphometry plus functional connectivity analyses explored neural correlates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Frailty distinguished CU from AD (area under the curve [AUC]\u00a0=\u00a00.85) and CU from FTLD (AUC\u00a0=\u00a00.88) but not AD from FTLD (AUC\u00a0=\u00a00.59). Higher frailty was linked to widespread gray matter loss, with temporal involvement in CU and stronger frontotemporal effects in dementia, particularly FTLD. Connectivity analyses showed fronto\u2010temporo\u2010posterior reductions and increased connectivity across the frailty network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Findings position frailty as a promising marker for identifying AD and FTLD relative to CU individuals, linked with brain health alterations in Latin American populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71232","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:00:21Z","timestamp":1776855621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America"],"prefix":"10.1002","volume":"22","author":[{"given":"Joaquin","family":"Migeot","sequence":"first","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat) Universidad Adolfo Iba\u00f1ez Santiago de Chile, Metropolitan Region of Santiago  \u00a0 Chile"},{"name":"Global Brain Health Institute (GBHI) Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Wen","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat) Universidad Adolfo Iba\u00f1ez Santiago de Chile, Metropolitan Region of Santiago  \u00a0 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Gonzalez\u2010Gomez","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat) Universidad Adolfo Iba\u00f1ez Santiago de Chile, Metropolitan Region of Santiago  \u00a0 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernan","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat) Universidad Adolfo Iba\u00f1ez Santiago de Chile, Metropolitan Region of Santiago  \u00a0 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Aguillon","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia Facultad de Medicina Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Alberto","family":"Avila\u2010Funes","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Ense\u00f1anza Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"},{"name":"Univ. 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