{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:22:22Z","timestamp":1782537742732,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Accelerated long\u2010term forgetting (ALF) may represent one of the earliest cognitive changes in Alzheimer's disease (AD). However, whether ALF emerges in the preclinical stage of autosomal\u2010dominant AD (ADAD) is unclear, and its underlying mechanisms are poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We assessed ALF via long\u2010term memory testing, sleep physiology via overnight electroencephalography, and AD neuropathology burden via positron emission tomography in 28 non\u2010demented\n                      <jats:italic>PSEN1<\/jats:italic>\n                      E280A mutation carriers and 24 healthy non\u2010carriers from a Colombian ADAD kindred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Non\u2010demented carriers exhibited ALF despite having intact short\u2010term memory. They also demonstrated isolated reduction in parietal sleep spindle (SS) power, whereas other aspects of sleep remained intact. Reduced parietal SS power was associated with both ALF and greater tau burden in the precuneus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>ALF is among the earliest cognitive changes in preclinical ADAD, and the specific disruption of parietal SS power may be a key neurophysiologic mechanism linking early tau accumulation to ALF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71235","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T03:08:08Z","timestamp":1771816088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term forgetting, sleep, and tau in autosomal\u2010dominant Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Jason C.","family":"You","sequence":"first","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex C.","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Berezuk","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy T.","family":"Noriega\u2010Makarskyy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Baena","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia Facultad de Medicina Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Munera","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enmanuelle","family":"Pardilla\u2010Delgado","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Ramirez\u2010Gomez","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Aguillon","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia Facultad de Medicina Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Averi","family":"Giudicessi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Psychological &amp; Brain Sciences Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo E.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Psychological &amp; Brain Sciences Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Cronin\u2010Golomb","sequence":"additional","affiliation":[{"name":"Department of Psychological &amp; Brain Sciences Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice D.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9714-8244","authenticated-orcid":false,"given":"Yakeel T.","family":"Quiroz","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Grupo de Neurociencias de Antioquia Facultad de Medicina Universidad de Antioquia  Medell\u00edn Colombia"},{"name":"Department of Psychological &amp; Brain Sciences Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1424"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/DNND.S228939"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000827"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30078-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51245"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5539"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30434-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00693-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2762"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2017.06.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.2334"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.13383"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105031"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau6550"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.08.017"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0503-19.2019"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12616"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.6240"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0309-5"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8376108"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac135"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4035"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3324"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02811-z"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0260-17.2017"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14424"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.78191"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab272"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.3889"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad304"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02335-1"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2019.6"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.4851"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-240360"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610292001157"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/09084280701508655"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.10.009"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/156869"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa112"},{"key":"e_1_2_8_42_1","volume-title":"Observed brain dynamics","author":"Mitra PP","year":"2008"},{"key":"e_1_2_8_43_1","unstructured":"MitraPP.Chronux analysis software.2018."},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207942"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v031.i10"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4907"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00765-5"},{"key":"e_1_2_8_48_1","volume-title":"Model selection and multimodel inference : A practical information\u2010theoretic approach","author":"Burnham KP","year":"2002"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.05.041"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-022-00620-6"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44220-024-00259-5"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00109"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000214459"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-014-0472-6"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010612"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-025-03089-8"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71235","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:08:51Z","timestamp":1782533331000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/alz.71235"],"URL":"https:\/\/doi.org\/10.1002\/alz.71235","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71235"}}