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Statistical Analysis for Genetic Epidemiology (S.A.G.E.) estimates were highest for Dutch isolate (78.3%), followed by non\u2010Hispanic Blacks (39.1%), Dominicans (31.7%), and non\u2010Hispanic Whites (29.1%), adjusted for age and sex.\n                      <jats:italic>APOE<\/jats:italic>\n                      adjustment reduced estimates (4.9% on average), while study adjustment primarily affected groups that included multiple studies. Sequential Oligogenic Linkage Analysis Routines (SOLAR\u2010Eclipse) estimates were higher (45.2% to 80.2%) than S.A.G.E. (20.4% to 80.9%) but behaved in parallel, except for the Dutch isolate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>LOAD heritability estimates are dependent on study population and may reflect or indicate differences in LOAD risk by population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71236","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T16:06:01Z","timestamp":1774454761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dissecting Alzheimer's disease heritability across populations"],"prefix":"10.1002","volume":"22","author":[{"given":"Shiying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Bush","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"Kunkle","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics Dr. John T. Macdonald Foundation Department of Human Genetics Department of Neurology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goldie S.","family":"Byrd","sequence":"additional","affiliation":[{"name":"Maya Angelou Center for Health Equity Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Reitz","sequence":"additional","affiliation":[{"name":"Gertrude H. Sergievsky Center Taub Institute for Research on Alzheimer's Disease and the Aging Brain Department of Neurology Columbia University Department of Epidemiology Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tosto","sequence":"additional","affiliation":[{"name":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University Irving Medical Center Columbia University; Department of Neurology Columbia University Irving Medical Center Columbia University; The Gertrude H. Sergievsky Center College of Physicians and Surgeons Columbia University Irving Medical Center Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Rajabli","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics Dr. John T. Macdonald Foundation Department of Human Genetics Department of Neurology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M.","family":"Caban\u2010Holt","sequence":"additional","affiliation":[{"name":"Maya Angelou Center for Health Equity Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cuccaro","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics Dr. John T. Macdonald Foundation Department of Human Genetics Department of Neurology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takiyah","family":"Starks","sequence":"additional","affiliation":[{"name":"Maya Angelou Center for Health Equity Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry D.","family":"Adams","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics Dr. John T. Macdonald Foundation Department of Human Genetics Department of Neurology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briseida E.","family":"Feliciano","sequence":"additional","affiliation":[{"name":"Universidad Central del Caribe  Bayam\u00f3n Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufus","family":"Akinyemi","sequence":"additional","affiliation":[{"name":"Neuroscience and Ageing Research Unit College of Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery M.","family":"Vance","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics Dr. John T. 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