{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:01:51Z","timestamp":1780048911415,"version":"3.53.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Most Alzheimer's disease (AD) cases show mixed pathology, with \u03b1\u2010synuclein (\u03b1Syn) aggregates present in a substantial proportion. The cerebrospinal fluid (CSF) \u03b1\u2010synuclein seed amplification assay (\u03b1S\u2010SAA) enables in vivo detection of pathogenic \u03b1Syn aggregates, but its clinical significance remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We prospectively evaluated 108 individuals with mild cognitive impairment or mild dementia due to suspected AD undergoing lumbar puncture for anti\u2010amyloid therapy (ATT) eligibility. CSF AD biomarkers and \u03b1S\u2010SAA were analyzed alongside cognitive, olfactory, and rapid eye movement sleep behavior disorder (RBD) assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Of 65 participants with biomarker\u2010confirmed AD, 21 (32.3%) were \u03b1S\u2010SAA positive. Positivity was linked to older age at testing and self\u2010reported olfactory impairment (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004), but not other demographic or cognitive features. Within the \u03b1S\u2010SAA\u2013positive group, RBD presence correlated with faster seeding kinetics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\u03b1S\u2010SAA positivity is common in early AD and associated with olfactory dysfunction. Longitudinal follow\u2010up is required to test if assay status predicts response to ATTs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71240","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:03:02Z","timestamp":1774350182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alpha\u2010synuclein co\u2010pathology in a real\u2010world early Alzheimer's disease cohort"],"prefix":"10.1002","volume":"22","author":[{"given":"Tamara","family":"Shiner","sequence":"first","affiliation":[{"name":"Cognitive Neurology Unit, Neurological Institute Tel Aviv Medical Center  Tel Aviv Israel"},{"name":"Gray Faculty of Medical &amp; Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Movement Disorders Unit, Neurological Institute Tel Aviv Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talya","family":"Nathan","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Unit, Neurological Institute Tel Aviv Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mori Hai","family":"Levy","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Unit, Neurological Institute Tel Aviv Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya Bar","family":"David","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Unit, Neurological Institute Tel Aviv Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurit","family":"Omer","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Unit, Neurological Institute Tel Aviv Medical Center  Tel Aviv Israel"},{"name":"Movement Disorders Unit, Neurological Institute Tel Aviv Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anan Abu","family":"Awad","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Unit, Neurological Institute Tel Aviv Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissa","family":"Ash","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Unit, Neurological Institute Tel Aviv Medical Center  Tel Aviv Israel"},{"name":"Gray Faculty of Medical &amp; Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mali Gana","family":"Weisz","sequence":"additional","affiliation":[{"name":"Laboratory of Biomarkers and Genomics of Neurodegeneration  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orly","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Laboratory of Biomarkers and Genomics of Neurodegeneration  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifat","family":"Alcalay","sequence":"additional","affiliation":[{"name":"Division of Clinical Laboratories Tel Aviv Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Regev","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical &amp; Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"Neuroimmunology Unit Tel Aviv Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lamoureux","sequence":"additional","affiliation":[{"name":"Amprion, Inc.  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