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For A\u03b242\/40, p\u2010tau217, and p\u2010tau217\/A\u03b242, we evaluated amyloid positron emission tomography positivity classification performance and associations with cognitive trajectories using sex interactions and sex\u2010stratified models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among CU participants, men had lower A\u03b242 and GFAP, and higher p\u2010tau217\/A\u03b242. Among the CI group, GFAP, p\u2010tau217 and p\u2010tau217\/A\u03b242 were higher in women. Overall classification performance was similar across sexes; however, p\u2010tau217 and p\u2010tau217\/A\u03b242 showed higher specificity and positive predictive value in CU women, with the opposite pattern observed in CI participants. In CU participants, p\u2010tau217 and p\u2010tau217\/A\u03b242 predicted modified Preclinical Alzheimer Cognitive Composite decline only in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Sex\u2010specific plasma biomarker cutoffs may not be necessary. However, sex influences biomarker levels, classification metrics, and prognostic value, highlighting the importance of considering sex differences when interpreting biomarker results and optimizing trial enrichment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71244","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:16:36Z","timestamp":1772968596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sex differences in Alzheimer's disease plasma biomarker levels and clinical utility"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-4597","authenticated-orcid":false,"given":"Marta","family":"Mil\u00e0\u2010Alom\u00e0","sequence":"first","affiliation":[{"name":"Northern California Institute for Research and Education  San Francisco California USA"},{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Hausle","sequence":"additional","affiliation":[{"name":"Northern California Institute for Research and Education  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Myoraku","sequence":"additional","affiliation":[{"name":"Northern California Institute for Research and Education  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Sorensen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"},{"name":"University of California Berkeley\/San Francisco Graduate Program in Bioengineering Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Thropp","sequence":"additional","affiliation":[{"name":"Northern California Institute for Research and Education  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie M.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Northern California Institute for Research and Education  San Francisco California USA"},{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8644-7724","authenticated-orcid":false,"given":"Duygu","family":"Tosun","sequence":"additional","affiliation":[{"name":"Northern California Institute for Research and Education  San Francisco California USA"},{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000403\u20103"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12697"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac333"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14315"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201001925\u2010w"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105805"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70038"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001469\u2010w"},{"key":"e_1_2_8_11_1","unstructured":"C2N Diagnotics.C2N submits US FDA regulatory filing for its Alzheimer's disease blood test.Precivity October 1 2025. 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