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Adherence was not different between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.18). At 12 months, PRT significantly improved ADAS\u2010Cog\u2010Plus scores (estimated mean difference: \u22120.18; 95% confidence interval [CI: \u22120.35, \u22120.01];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04). Planned contrasts stratified by sex showed a significant PRT effect on ADAS\u2010Cog\u2010Plus scores for females (mean difference: \u22120.27; 95% CI: [\u22120.49, \u22120.05];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), but not for males. PRT also significantly reduced C\u2010reactive protein (estimated mean difference: \u22122.93; 95% CI: [\u22125.36, \u22120.49];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02). No significant differences were observed for other secondary outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>PRT may have a small beneficial effect on cognitive function in SVCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>This trial was registered with ClinicalTrials.gov (NCT02669394).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71245","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:18:27Z","timestamp":1772990307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Resistance training and subcortical vascular cognitive impairment: A 12\u2010month randomized trial"],"prefix":"10.1002","volume":"22","author":[{"given":"Teresa","family":"Liu\u2010Ambrose","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of British Columbia  Vancouver British Columbia Canada"},{"name":"Djavad Mowafaghian Centre for Brain Health University of British Columbia  Vancouver British Columbia Canada"},{"name":"Centre for Aging SMART at Vancouver Coastal Health Vancouver Coastal Health Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan S.","family":"Falck","sequence":"additional","affiliation":[{"name":"Djavad Mowafaghian Centre for Brain Health University of British Columbia  Vancouver British Columbia Canada"},{"name":"Centre for Aging SMART at Vancouver Coastal Health Vancouver Coastal Health Research Institute  Vancouver British Columbia Canada"},{"name":"School of Biomedical Engineering University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Dao","sequence":"additional","affiliation":[{"name":"Centre for Aging SMART at Vancouver Coastal Health Vancouver Coastal Health Research Institute  Vancouver British Columbia Canada"},{"name":"Department of Radiology University of British Columbia  Vancouver British Columbia Canada"},{"name":"International Collaboration on Repair Discoveries  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Crockett","sequence":"additional","affiliation":[{"name":"Djavad Mowafaghian Centre for Brain Health University of British Columbia  Vancouver British Columbia Canada"},{"name":"Centre for Aging SMART at Vancouver Coastal Health Vancouver Coastal Health Research Institute  Vancouver British Columbia Canada"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy K.","family":"Barha","sequence":"additional","affiliation":[{"name":"Djavad Mowafaghian Centre for Brain Health University of British Columbia  Vancouver British Columbia Canada"},{"name":"Centre for Aging SMART at Vancouver Coastal Health Vancouver Coastal Health Research Institute  Vancouver British Columbia Canada"},{"name":"Barha Brain Health Laboratory Faculty of Kinesiology University of Calgary,Calgary  Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narlon C. 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