{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:50:28Z","timestamp":1787313028466,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      We evaluated a pragmatic screening strategy combining brief cognitive assessment with plasma phosphorylated tau217 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010tau217) in an elderly health screening cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Participants completed the Memory and Executive Screening (MES) test and plasma biomarker assessment. Cognitive impairment was defined using individualized residual norms derived from an internal reference sample. The\n                      <jats:italic>p<\/jats:italic>\n                      \u2010tau217 thresholds were positive predictive value (PPV) \u2010oriented and anchored to age\u2010 and cognitive status\u2010specific prior probabilities of amyloid\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      (A\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ) pathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      MES\u2010defined cognitive impairment (\u2264\u22122 standard deviation [SD] deviation after adjustment for demographics) was identified in 12.4% of participants. In cognitively unimpaired (CU) individuals, age\u2010specific thresholds targeting a PPV of 0.7 yielded an overall\n                      <jats:italic>p<\/jats:italic>\n                      \u2010tau217 positivity rate of 11.8%, increasing from 3.5% (&lt;\u00a060 years) to 6.3% (60\u201370 years) and 25.9% (\u226570 years). Among cognitively impaired (CI) participants, 26.6% were\n                      <jats:italic>p<\/jats:italic>\n                      \u2010tau217 positive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This framework supports practical integration of plasma biomarkers into community\u2010based screening, with longitudinal follow\u2010up needed to further refine threshold selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Regression\u2010based residual method reduced education bias, identifying 12.4% with cognitive impairment individuals.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Fully automated chemiluminescent assay enabled practical, large\u2010scale biomarker implementation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Brief screening strategy supports early detection, clinical trial recruitment, and resource allocation in under\u2010resourced regions.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71251","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:01:21Z","timestamp":1773136881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Implementing plasma p\u2010tau217 and cognitive testing for Alzheimer's screening in low\u2010education populations in central China"],"prefix":"10.1002","volume":"22","author":[{"given":"Shuai","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodi","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changming","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Neurology Nanyang Central Hospital  Nanyang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinsheng","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaifeng Central Hospital  Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenquan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology Pingmei Shenma Medical Group General Hospital  Pingdingshan Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwang","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhumadian Central Hospital  Zhumadian Henan 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Hospital  Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Neurology Luoyang Central Hospital  Luoyang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkui","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital)  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cao","sequence":"additional","affiliation":[{"name":"Vazyme Biotech Co., Ltd  Nanjing 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