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amyloid, and as a proof of concept, whether plasma amyloid beta (A\u03b2)42\/A\u03b240 with OSA severity improves detection of amyloidosis and tau pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In 120 cognitively normal older adults (70 with CSF data) from New York University sleep and aging studies (2013\u20132021), OSA severity was measured using apnea\/hypopnea index with 4% desaturation; plasma A\u03b240, A\u03b242, tau, and neurofilament light chain (NfL) via single molecule array; CSF amyloid and tau via enzyme\u2010linked immunosorbent assay. Associations evaluated adjusted correlations and generalized models; receiver operating characteristic analyses evaluated diagnostic accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      OSA severity correlated with plasma A\u03b240 (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.21), A\u03b242 (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.26), and A\u03b242\/A\u03b240 (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.20). Plasma tau and NfL associations depended on CSF\u2013A\u03b242. OSA severity with A\u03b242\/A\u03b240 improved CSF amyloidosis (area under the curve [AUC]\u00a0=\u00a00.78) and tau pathology (AUC\u00a0=\u00a00.71) detection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>OSA severity relates to elevated plasma A\u03b2 and, with CSF amyloid, to tau\/NfL. Combined plasma and OSA measures aid non\u2010invasive AD associations\u2019 detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71270","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:29:54Z","timestamp":1772998194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Obstructive sleep apnea severity, Alzheimer's disease plasma markers, and CSF brain amyloidosis and tau pathology"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7438-2628","authenticated-orcid":false,"given":"Omonigho Michael","family":"Bubu","sequence":"first","affiliation":[{"name":"Healthy Brain Aging and Sleep Center Department of Psychiatry New York University Grossman School of Medicine  New York New York USA"},{"name":"Institute of Excellence in Health Equity Department of Population Health New York University Grossman School of Medicine  New 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