{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:22:26Z","timestamp":1790220146940,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG058066"],"award-info":[{"award-number":["AG058066"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Cognitive SuperAgers (SAs) are individuals aged 80+ with exceptional episodic memory performance for their age, exceeding middle\u2010aged adult norms. This study integrates family\u2010 and association\u2010based methods to identify genetic variants associated with SAs in the Midwestern Amish population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010three Amish SAs were grouped into 16 pedigrees for parametric and non\u2010parametric linkage analysis. Variants in linked regions (heterogeneity logarithm of the odds [HLOD] or Kong and Cox logarithm of the odds [LOD*] \u2265 3) were tested for association with SAs using two contrasts: SA versus Alzheimer's disease (AD;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040) and SA versus cognitively unimpaired (CU), age\u2010matched non\u2010SA individuals (CU80+;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0157).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Evidence of linkage for SAs was observed on chromosomes 1, 2, 7, 16, and 20, with the strongest signal around the AD\u2010associated locus\n                      <jats:italic>WDR12<\/jats:italic>\n                      on chromosome 2. Association analysis for SA versus AD identified eight variants in\n                      <jats:italic>HIVEP3<\/jats:italic>\n                      (chromosome 1) that were nominally significant when comparing SA versus CU80+.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      <jats:italic>WDR12<\/jats:italic>\n                      and\n                      <jats:italic>HIVEP3<\/jats:italic>\n                      are potential candidate genes contributing to SAs in the Amish population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71293","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:19:32Z","timestamp":1774628372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>WDR12<\/i>\n                    and\n                    <i>HIVEP3<\/i>\n                    are contributors to cognitive preservation in Amish SuperAgers"],"prefix":"10.1002","volume":"22","author":[{"given":"Daniel","family":"Dorfsman","sequence":"first","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Dr. John T. Macdonald Foundation Department of Human Genetics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Prough","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Gulyayev","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Caywood","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E.","family":"Clouse","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharlene D.","family":"Herington","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan H.","family":"Slifer","sequence":"additional","affiliation":[{"name":"John P. 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