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Machine learning ensemble models\u00a0classified participants as either normal controls (NC) or as individuals with PPA and a subsequent autopsy\u2010confirmed neuropathologic diagnosis of either Alzheimer's disease (AD) or 4\u2010repeat tauopathy under the umbrella of frontotemporal lobar degeneration (FTLD\u20104Rtau).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>All models successfully distinguished transcribed narratives of AD from those with FTLD\u20104Rtau, as well as the narratives of NC from those with PPA. Feature permutation revealed diverging patterns of contribution to classification depending upon language domain and disease pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The usage of artificial intelligence in the context of naturalistic language tasks may ultimately serve as a complementary aid in differential diagnosis of PPA disease pathologies and in uncovering avenues for disease\u2010specific interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71294","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:38:26Z","timestamp":1773999506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identifying neuropathologic disease in primary progressive aphasia using narrative speech"],"prefix":"10.1002","volume":"22","author":[{"given":"Daniel B.","family":"Gutstein","sequence":"first","affiliation":[{"name":"Mesulam Institute for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Iorga","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Stocks","sequence":"additional","affiliation":[{"name":"Mesulam Institute for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Gill","sequence":"additional","affiliation":[{"name":"Mesulam Institute for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Preventive Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Sleeman","sequence":"additional","affiliation":[{"name":"School of Professional Studies Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar D.","family":"Gefen","sequence":"additional","affiliation":[{"name":"Mesulam Institute for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Los","sequence":"additional","affiliation":[{"name":"Mesulam Institute for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Nelson","sequence":"additional","affiliation":[{"name":"Mesulam Institute for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changiz","family":"Geula","sequence":"additional","affiliation":[{"name":"Mesulam Institute for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Cell and Developmental Biology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Mesulam Institute for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Neurology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Parrish","sequence":"additional","affiliation":[{"name":"Mesulam Institute for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Biomedical Engineering Northwestern University  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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