{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:07:58Z","timestamp":1787162878513,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Individuals with Down syndrome (DS) are at risk for Alzheimer's disease (AD). However, diagnosis remains challenging due to variability of intellectual ability and symptom presentation. To investigate whether serum AD biomarkers enhance accuracy of the German version of the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID\u2010G), we combined test scores with neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010eight DS individuals (49% female) completed the DSQIID\u2010G; previous cohort data were added for a pooled sample (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0164, 47% female). Serum NfL and GFAP were assessed using the automated microfluid Ella system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Combining the DSQIID\u2010G with NfL or GFAP resulted in improved accuracy in every diagnostic subgroup. The Youden index in the pooled samples yielded a cut\u2010off score at 6.5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The DSQIID\u2010G is a robust screening tool and its combination with AD blood biomarkers aids earlier identification of individuals requiring further diagnostics for DS\u2010associated AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71296","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:50:36Z","timestamp":1773996636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Combining blood biomarkers and the German version of the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID\u2010G) for diagnosing cognitive decline in Down syndrome"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3211-9105","authenticated-orcid":false,"given":"Olivia","family":"Wagemann","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Ludwig\u2010Maximilians\u2010University (LMU) Munich  Munich Germany"},{"name":"German Center for Neurodegenerative Disease (DZNE) Feodor\u2010Lynen\u2010Stra\u00dfe  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ludwig\u2010Maximilians\u2010University (LMU) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Wlasich","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ludwig\u2010Maximilians\u2010University (LMU) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Sandk\u00fchler","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ludwig\u2010Maximilians\u2010University (LMU) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Prix","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ludwig\u2010Maximilians\u2010University (LMU) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stockbauer","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ludwig\u2010Maximilians\u2010University (LMU) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Marth","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ludwig\u2010Maximilians\u2010University (LMU) Munich  Munich Germany"},{"name":"German Center for Neurodegenerative Disease (DZNE) Feodor\u2010Lynen\u2010Stra\u00dfe  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"J\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ludwig\u2010Maximilians\u2010University (LMU) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Halbgebauer","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ulm  Ulm Germany"},{"name":"German Center for Neurodegenerative Disease (DZNE) Oberer Eselsberg  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrettin","family":"Tumani","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter U.","family":"H\u00f6glinger","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ludwig\u2010Maximilians\u2010University (LMU) Munich  Munich Germany"},{"name":"German Center for Neurodegenerative Disease (DZNE) Feodor\u2010Lynen\u2010Stra\u00dfe  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy) Feodor\u2010Lynen\u2010Stra\u00dfe  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ludwig\u2010Maximilians\u2010University (LMU) Munich  Munich Germany"},{"name":"German Center for Neurodegenerative Disease (DZNE) Feodor\u2010Lynen\u2010Stra\u00dfe  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy) Feodor\u2010Lynen\u2010Stra\u00dfe  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"N\u00fcbling","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ludwig\u2010Maximilians\u2010University (LMU) Munich  Munich Germany"},{"name":"German Center for Neurodegenerative Disease (DZNE) Feodor\u2010Lynen\u2010Stra\u00dfe  Munich 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