{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:02:01Z","timestamp":1780048921626,"version":"3.53.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Family relationships and friendships are important for cognitive health, yet how their quality relates to dementia risk remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This prospective cohort study included 104,093 UK Biobank participants aged 40 to 69 years who were dementia free within the first 4 years. Relationship satisfaction was categorized as satisfied or dissatisfied. Cox regression models assessed associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Over 13.56 years, 1359 developed dementia. In the fully adjusted model, dissatisfied (vs. satisfied) family relationships were associated with elevated dementia risk (hazard ratio [HR]: 1.334, 95% confidence interval [CI]: 1.069\u20131.663), driven primarily by very dissatisfied participants (HR: 1.663). Friendship dissatisfaction showed no significant association with dementia risk (HR: 1.060, 95% CI: 0.752\u20131.494). Overall relationship dissatisfaction was associated with increased dementia risk (HR 1.265, 95% CI 1.035\u20131.546), though becoming non\u2010significant after adjustment for additional psychological factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Family relationship quality may represent a risk factor of dementia warranting consideration in prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71303","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:44:27Z","timestamp":1773891867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of family and friend relationship satisfaction with incident dementia: A prospective cohort study of 104,093 participants"],"prefix":"10.1002","volume":"22","author":[{"given":"Dandan","family":"Sheng","sequence":"first","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuye","family":"Ning","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Beijing 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