{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:29:54Z","timestamp":1787862594693,"version":"build-2784847793"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>ARIA often shows posterior and watershed predominance, indicating region\u2010specific vascular vulnerability beyond amyloid burden alone.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Reduced autoregulatory reserve in posterior territories may predispose to blood\u2010brain\u2010barrier disruption during anti\u2010amyloid therapy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Watershed regions are hemodynamically fragile, lowering the threshold for vasogenic edema or microhemorrhage after amyloid mobilization.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>ARIA may represent a PRES\u2010like neurovascular decompensation within an amyloid\u2010compromised vascular bed.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71304","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:52:16Z","timestamp":1773892336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["ARIAs are not random: A posterior and border\u2010zone vascular vulnerability model"],"prefix":"10.1002","volume":"22","author":[{"given":"Alessandro","family":"Introna","sequence":"first","affiliation":[{"name":"Department of Translational Biomedicine and Neuroscience, Neurology Unit University of Bari Aldo Moro  Bari Italy"},{"name":"Neurology Unit \u201cL. Amaducci,\u201d AOU Consorziale Policlinico  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(25)01329\u20107"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213483"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom16010089"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.71044"},{"key":"e_1_2_6_6_1","unstructured":"The diagnosis of posterior reversible encephalopathy syndrome\u2014The Lancet Neurology n.d. 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