{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:01:28Z","timestamp":1791900088323,"version":"4.3.4"},"reference-count":73,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD), a neurodegenerative disease, involves early alterations in the gut microbiota. Bile acids (BAs), which are metabolites produced by the microbiota, may impact brain function through the gut\u2010brain axis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      By reference to multimodal datasets from the Chinese Preclinical Alzheimer's Disease Study (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01397) and the Alzheimer's Disease Neuroimaging Initiative (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01275), we analyzed differences in BA levels and their associations with AD biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Lithocholic acid (LCA) \u2013family BAs are associated with the amyloid\u2010\u03b2 status. Longitudinal changes in BA levels correlated with amyloid and tau pathologies. LCA and the deoxycholic acid (DCA) family exhibited predictive value with respect to AD pathology. Imaging transcriptomic analyses suggested that BAs modulated amyloid pathology through multiple mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>DCA\u2010 and LCA\u2010family BAs were proposed as molecular bridges that connect age signatures with AD pathology. They represent a new avenue for the development of biomarkers and therapeutic interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71307","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:59:48Z","timestamp":1773914388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bile acids are associated with baseline and longitudinal amyloid and tau pathology in patients with Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Wenjie","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine The Second Xiangya Hospital Central South University  Changsha Hunan Province China"},{"name":"Department of Nuclear Medicine &amp; PET Center Huashan Hospital Fudan University  Shanghai 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and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET Center Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingren","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Neuroscience Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China The Second Affiliated Hospital Guangzhou Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jia","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine and Shanghai Key Laboratory of Diabetes 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