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Alterations in the connectomes discriminate different diagnostic groups and predict cognitive decline to a higher extent than conventional PET measures. We introduce a novel gene\u2010specific transcription network analysis that linked individual tau and amyloid connectomes to a common transcriptomic profile of apoptosis, with the tau connectome being specifically related to pyrimidine metabolism, and the amyloid connectome to histone acetylation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Individual molecular connectome mapping provides a novel and sensitive framework to monitor AD progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71310","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:10:05Z","timestamp":1774584605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping individual molecular connectomes in Alzheimer's 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