{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:56Z","timestamp":1783322216586,"version":"3.54.6"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARFD\u201024\u20101308800"],"award-info":[{"award-number":["AARFD\u201024\u20101308800"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG072547"],"award-info":[{"award-number":["R01 AG072547"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19AG074865"],"award-info":[{"award-number":["U19AG074865"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      <jats:italic>ABCA7<\/jats:italic>\n                      (ATP binding cassette subfamily A member 7) encodes a lipid transporter associated with increasing risk for Alzheimer's disease (AD). A 44\u2010base pair deletion in\n                      <jats:italic>ABCA7<\/jats:italic>\n                      (rs142076058; p.Arg578Alafs) is a strong risk factor in individuals of African ancestry (AA). However, the biological consequences of this deletion are poorly understood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We expressed the truncated ABCA7 protein in HEK and HepG2 cells to assess cellular localization and impact on lipid metabolism, respectively. Additionally, induced pluripotent stem cell (iPSC)\u2010derived neurons carrying the deletion were functionally assessed compared to isogenic controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Truncated ABCA7 localized to endoplasmic reticulum and plasma membranes similarly to the wild type in HEK cells but induced significant lipid droplet accumulation in HepG2 cells and iPSC\u2010derived neurons while reducing mitochondrial membrane potential in iPSC\u2010derived neurons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      These findings show that the AA\u2010specific\n                      <jats:italic>ABCA7<\/jats:italic>\n                      deletion disrupts lipid and mitochondrial homeostasis, supporting a mechanistic link between the\n                      <jats:italic>ABCA7<\/jats:italic>\n                      deletion and increased AD risk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71312","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:07:02Z","timestamp":1774926422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disrupted lipid homeostasis as a pathogenic mechanism in\n                    <i>ABCA7<\/i>\n                    \u2010associated Alzheimer's disease risk"],"prefix":"10.1002","volume":"22","author":[{"given":"Younji","family":"Nam","sequence":"first","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke A.","family":"DeRosa","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aura M.","family":"Ramirez","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biniyam A.","family":"Ayele","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Department of Neurology Addis Ababa University School of Medicine  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Whitehead\u2010Gay","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry D.","family":"Adams","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles G.","family":"Golightly","sequence":"additional","affiliation":[{"name":"John P. 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Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Dr. John T. Macdonald Foundation Department of Human Genetics University of Miami Miller School of Medicine  Miami, Forida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufus","family":"Akinyemi","sequence":"additional","affiliation":[{"name":"Neuroscience and Ageing Research Unit Institute for Advanced Medical Research &amp; Training University of Ibadan College of Medicine  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Sarfo","sequence":"additional","affiliation":[{"name":"Department of Medicine Kwame Nkrumah University of Science &amp; Technology  Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Akpalu","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ghana Medical School\/Korle Bu Teaching Hospital  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Cuccaro","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Dr. John T. Macdonald Foundation Department of Human Genetics University of Miami Miller School of Medicine  Miami, Forida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Population &amp; Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Caban\u2010Holt","sequence":"additional","affiliation":[{"name":"Department of Social Sciences and Health Policy Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Reitz","sequence":"additional","affiliation":[{"name":"Gertrude H. 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