{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:27:26Z","timestamp":1787905646914,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH000500"],"award-info":[{"award-number":["MOH000500"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) is the first large Southeast Asian randomized controlled trial of multidomain lifestyle interventions in older adults at increased dementia risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Baseline assessments included sociodemographic, cognitive, lifestyle, and clinical risk factors. Recruitment strategies and adaptations to coronavirus disease 2019 (COVID\u201019) restrictions and operational challenges were documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 3841 individuals were pre\u2010screened, with 1218 randomized 1:1 to a Structured Lifestyle Intervention or a Self\u2010Guided Intervention (606 each; three exclusions per arm). Participants had a mean age of 68.7 years and a mean of 12.5 years of education; 96.4% were Chinese. High rates of inactivity, limited cognitive engagement, and suboptimal diet were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Despite pandemic disruptions, SINGER achieved its recruitment target through adaptive strategies, enrolling a cohort with significant scope for dementia risk reduction and positioned to test the effectiveness of multidomain lifestyle interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICALTRIALS<\/jats:title>\n                    <jats:p>Gov ID: NCT05007353<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71313","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:53:58Z","timestamp":1775541238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Baseline characteristics of the SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) multidomain dementia prevention randomized controlled trial and insights from the recruitment process"],"prefix":"10.1002","volume":"22","author":[{"given":"Kwong Hsia","family":"Yap","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Memory, Ageing and Cognition Centre (MACC), Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Chen","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie J. Y.","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, Memory, Ageing and Cognition Centre (MACC) National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaendran","family":"Kandiah","sequence":"additional","affiliation":[{"name":"Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miia","family":"Kivipelto","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Division of Clinical Geriatrics, Center for Alzheimer Research Care Sciences and Society, Karolinska Institutet  Stockholm Sweden"},{"name":"Ageing Epidemiology Research Unit (AGE), School of Public Health Imperial College London  London UK"},{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell K. 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