{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:24:04Z","timestamp":1789219444573,"version":"build-2803163510"},"reference-count":83,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG068215"],"award-info":[{"award-number":["AG068215"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Sleep and circadian disturbances are early Alzheimer's disease (AD) features, yet mechanisms linking amyloid pathology, neuroinflammation, and sex differences remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We longitudinally assessed sleep, circadian rhythms, and cognition in female and male hAPP\n                      <jats:sup>SAA<\/jats:sup>\n                      knock\u2010in and control mice from 2 to 19 months using piezoelectric monitoring. Aged mice (15 months) received MW151, a glial cytokine inhibitor (2.5\u00a0mg\/kg, every other day, 6\u00a0weeks).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Only females exhibited midlife reductions in light\u2010phase sleep, increased rhythm fragmentation, and reduced rhythm stability, coinciding with selective reversal learning deficits, effects independent of amyloid or cytokine burden. MW151 increased light\u2010phase sleep and reduced cortical TNF\u2010\u03b1 without altering amyloid beta (A\u03b2) accumulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      HAPP\n                      <jats:sup>SAA<\/jats:sup>\n                      mice recapitulate female\u2010predominant non\u2010cognitive AD features, including sleep fragmentation and circadian instability preceding memory deficits. Sleep improved within weeks of MW151 treatment without A\u03b2 reductions, implicating neuroinflammatory signaling as a rapid, modifiable driver of AD\u2010related sleep disruption.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71314","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:20:46Z","timestamp":1774927246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glial cytokine modulation improves sleep and circadian disruption in female SAA knock\u2010in mice of Alzheimer's\u2010related pathology"],"prefix":"10.1002","volume":"22","author":[{"given":"Teresa","family":"Macheda","sequence":"first","affiliation":[{"name":"Department of Neuroscience University of Kentucky  Lexington Kentucky USA"},{"name":"Spinal Cord and Brain Injury Research Center University of Kentucky  Lexington Kentucky USA"},{"name":"Sanders\u2010Brown Center on 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Abou","family":"El\u2010Ezz","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Kentucky  Lexington Kentucky USA"},{"name":"Spinal Cord and Brain Injury Research Center University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Abou","family":"El\u2010Ezz","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Kentucky  Lexington Kentucky USA"},{"name":"Spinal Cord and Brain Injury Research Center University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherina","family":"Kohler","sequence":"additional","affiliation":[{"name":"Sanders\u2010Brown Center on Aging University of Kentucky  Lexington Kentucky USA"},{"name":"Department of Molecular &amp; Cellular Biochemistry University of Kentucky  Lexington Kentucky 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