{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:18:46Z","timestamp":1793121526885,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2023\u2010MSLH\u2010029"],"award-info":[{"award-number":["2023\u2010MSLH\u2010029"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Sleep disturbance is increasingly recognized as a risk factor for Alzheimer's disease (AD), but longitudinal clinical evidence linking sleep behaviors to cerebrospinal fluid (CSF) amyloid beta (A\u03b2) dynamics and related proteomic signatures remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 1205 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to examine associations between sleep disturbance, CSF A\u03b242 level, and cognition. To prioritize molecular candidates associated with these phenotypes, we integrated CSF proteomics with weighted gene co\u2010expression network analysis (WGCNA) and two\u2010sample Mendelian randomization (MR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Baseline sleep disturbance was associated with a faster rate of longitudinal CSF A\u03b242 decline. WGCNA identified a protein module associated with sleep disturbance and A\u03b242, within which MR supported effects of sleep disturbance on multiple proteins. Among these, interferon \u03b3\u2010inducible protein 16 is a candidate link between sleep disturbance and A\u03b2 pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings suggest that sleep disturbance accelerates A\u03b2 pathology, and implicate IFI16\u2010related pathway as a link between disrupted sleep and AD progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71316","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:10:41Z","timestamp":1774926641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Associations between sleep disturbance and cerebrospinal fluid A\u03b2, and shared proteomic signatures in Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Tianbai","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meichen","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital Dalian Medical University  Dalian China"},{"name":"Department of Neurology, The First Affiliated Hospital Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital Dalian Medical University  Dalian 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaibin","family":"Cai","sequence":"additional","affiliation":[{"name":"Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junliang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Le","sequence":"additional","affiliation":[{"name":"Key Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital Dalian Medical University  Dalian China"},{"name":"Neurology Program, Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer's Disease Neuroimaging 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