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We aimed to evaluate correlation of tau tracer retention with neuropsychological performance across the Alzheimer's disease (AD) continuum and non\u2010AD tauopathies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This study enrolled 178 patients with cognitive impairment and 60 volunteers. Participants were divided into AD continuum (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0120) and non\u2010AD tauopathy (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a098) groups and assessed using the Mini\u2010Mental State Examination (MMSE), Clinical Dementia Rating, Functional Activity Questionnaire, Wechsler Memory Scale\u2010Revised Logical Memory, Alzheimer's Disease Assessment Scale Cognitive subscale, Trail Making Test (TMT), word fluency, and the Japanese Adult Reading Test. Voxel\u2010based analysis was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In the AD continuum group, all cognitive test performances significantly correlated with tracer uptake, particularly in the left cortical areas. In the non\u2010AD tauopathy group, strong correlations were observed with MMSE and TMT Part B performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Neuropsychological performance and regional tau pathology distribution are correlated in patients with tauopathy, with differences between AD continuum and non\u2010AD tauopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>This trial is registered with UMIN Clinical Trials (UMIN\u2010CTR number: 000032027); submitted for registration on March 30, 2018; first patient enrolment was on July 3, 2018.<\/jats:p>\n                  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