{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:12:56Z","timestamp":1789423976707,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DR 445\/9\u20101"],"award-info":[{"award-number":["DR 445\/9\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010146","name":"Alzheimer Forschung Initiative","doi-asserted-by":"publisher","award":["p21059"],"award-info":[{"award-number":["p21059"]}],"id":[{"id":"10.13039\/100010146","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Sleep disturbances have been associated with Alzheimer's disease (AD), but their relevance in preclinical stages, such as subjective cognitive decline (SCD), and their relationship with brain pathology remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We used a portable sleep\u2010monitoring headband over four consecutive nights to assess sleep in 19 cognitively unimpaired (CU), 15 SCD, and 20 mild cognitive impairment (MCI) participants with available amyloid positron emission tomography (PET). Linear\u2010mixed\u2010effects models compared sleep parameters across groups, accounting for amyloid burden, age, sex, education, and recording. Regional and voxel\u2010wise analyses examined regional associations between sleep parameters and amyloid burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>MCI patients presented reduced N3 (i.e., deep sleep), while SCD individuals showed longer N1 (i.e., light sleep) duration compared to CU. Regional amyloid burden was associated with longer light and deep sleep in amyloid\u2010positive individuals. Higher education was linked to better sleep efficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Sleep changes may serve as early indicators of cognitive dysfunction and regional amyloid accumulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71326","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:19:56Z","timestamp":1775665196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Home\u2010based sleep monitoring reveals associations between amyloid accumulation and sleep alterations in individuals with subjective and mild cognitive impairment"],"prefix":"10.1002","volume":"22","author":[{"given":"Antonia","family":"Buchal","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine University of Cologne Faculty of Medicine and University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Dzialas","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University of Cologne Faculty of Medicine and University Hospital Cologne  Cologne Germany"},{"name":"Faculty of Mathematics and Natural Sciences University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Doering","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University of Cologne Faculty of Medicine and University Hospital Cologne  Cologne Germany"},{"name":"Institute for Neuroscience and Medicine II Molecular Organization of the Brain Research Centre Juelich Juelich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Giehl","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University of Cologne Faculty of Medicine and University Hospital Cologne  Cologne Germany"},{"name":"Institute for Neuroscience and Medicine II Molecular Organization of the Brain Research Centre Juelich Juelich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard N.","family":"Bischof","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University of Cologne Faculty of Medicine and University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Elmenhorst","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University of Cologne Faculty of Medicine and University Hospital Cologne  Cologne Germany"},{"name":"Institute for Neuroscience and Medicine II Molecular Organization of the Brain Research Centre Juelich Juelich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"van Eimeren","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University of Cologne Faculty of Medicine and University Hospital Cologne  Cologne Germany"},{"name":"Department of Neurology University of Cologne Faculty of Medicine and University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Drzezga","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University of Cologne Faculty of Medicine and University Hospital Cologne  Cologne Germany"},{"name":"Institute for Neuroscience and Medicine II Molecular Organization of the Brain Research Centre Juelich Juelich Germany"},{"name":"German Centre for Neurodegenerative Diseases  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-750X","authenticated-orcid":false,"given":"Merle C.","family":"Hoenig","sequence":"additional","affiliation":[{"name":"Department 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