{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:10Z","timestamp":1783322170871,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We investigated whether a multi\u2010day learning curve (MDLC), derived from remote digital cognitive assessments over 1 week, adds prognostic value to plasma phosphorylated tau at threonine 217 (p\u2010tau217) for predicting cognitive decline in cognitively unimpaired (CU) older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A total of 183 CU participants (mean age 73.3; 70% female) completed multi\u2010day digital cognitive tests and provided plasma p\u2010tau217. Linear mixed\u2010effects models evaluated the independent and combined effects of baseline p\u2010tau217 and MDLC on longitudinal cognitive decline over 2.5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Adding MDLC to p\u2010tau217 significantly explained longitudinal cognitive trajectory beyond p\u2010tau217 alone. Although higher p\u2010tau217 and lower MDLC were independently associated with steeper decline, individuals with both risk factors declined the fastest. Notably, those with elevated p\u2010tau217 level but preserved MDLC remained stable, distinguishing them from those at imminent risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Combining digital learning metrics with plasma p\u2010tau217 enables precise risk stratification. This approach identifies individuals most vulnerable to imminent decline, potentially enhancing screening for early preventive interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71328","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:12:33Z","timestamp":1774926753000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combining p\u2010tau217 and digital cognitive testing to predict cognitive decline"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9623-608X","authenticated-orcid":false,"given":"Hairin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Mass General Brigham Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Soberanes","sequence":"additional","affiliation":[{"name":"Department of Neurology Mass General Brigham Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roos J.","family":"Jutten","sequence":"additional","affiliation":[{"name":"Department of Neurology Alzheimer Center Amsterdam Amsterdam Neuroscience, Amsterdam UMC location VUmc  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Dubbelman","sequence":"additional","affiliation":[{"name":"Department of Neurology Mass General Brigham Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Sik","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Mass General Brigham Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gad A.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Neurology Mass General Brigham 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