{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:34:17Z","timestamp":1792233257405,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Both increased blood pressure variability (BPV) and impaired cerebral autoregulation (CA) have been linked to cerebral small vessel disease (CSVD) and cognitive performance, but whether they independently or interactively influence cognition remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 300 community\u2010dwelling participants. Dynamic CA, beat\u2010to\u2010beat BPV measures, and MRI\u2010based CSVD markers were quantified. Multivariate linear regression and mediation analyses assessed the associations and interactions between CA, BPV, CSVD, and Montreal Cognitive Assessment (MoCA) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Higher BPV was associated with greater CSVD burden. A significant interaction between CA and BPV indicated that the negative association between BPV and MoCA scores was evident only under impaired CA. Mediation analyses demonstrated that BPV influenced MoCA score directly rather than through CSVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Increased BPV and impaired CA interacted and are associated with poorer cognitive performance independently of detectable CSVD, suggesting a potential link between hemodynamic instability and cognitive vulnerability in community\u2010dwelling older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71329","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:03:45Z","timestamp":1775210625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interactions between blood pressure variability, cerebral autoregulation, and covert cerebral small vessel disease in relation to cognitive performance in community\u2010dwelling older adults"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2204-4923","authenticated-orcid":false,"given":"Nai\u2010Fang","family":"Chi","sequence":"first","affiliation":[{"name":"Department of Neurology School of Medicine, National Yang Ming Chiao Tung University College of Medicine  Taipei Taiwan"},{"name":"Division of Cerebrovascular Diseases Neurological Institute, Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ning","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Healthy Longevity and Aging Sciences National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Center for Geriatric and Gerontology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Jen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology School of Medicine, National Yang Ming Chiao Tung University College of Medicine  Taipei Taiwan"},{"name":"Division of Cerebrovascular Diseases Neurological Institute, Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Min","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Cardiovascular Research Center, National Yang Ming Chiao Tung University College of Medicine Taipei Taiwan"},{"name":"Division of Faculty Development Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medical Education Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Cardiovascular Research Center, National Yang Ming Chiao Tung University College of Medicine Taipei Taiwan"},{"name":"Division of Faculty Development Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medical Education Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology School of Medicine, National Yang Ming Chiao Tung University College of Medicine  Taipei Taiwan"},{"name":"Division of Cerebrovascular Diseases Neurological Institute, Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Ping","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neurology School of Medicine, National Yang Ming Chiao Tung University College of Medicine  Taipei Taiwan"},{"name":"Division of Cerebrovascular Diseases Neurological Institute, Taipei Veterans General Hospital Taipei 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