{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:12Z","timestamp":1783322172066,"version":"3.54.6"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG062581"],"award-info":[{"award-number":["AG062581"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG069502"],"award-info":[{"award-number":["AG069502"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG066511"],"award-info":[{"award-number":["AG066511"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>In murine models of Alzheimer's disease (AD), lesioning the locus coeruleus\u2013norepinephrine (LC\u2010NE) system with DSP\u20104 exacerbates AD\u2010like neuropathology and cognitive impairment. However, the impact of LC lesions during prodromal stages is poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>TgF344\u2010AD and wild\u2010type rats received monthly injections of DSP\u20104 or saline from 1\u20135 months of age, a time point preceding forebrain plaque or tangle deposition in TgF344\u2010AD rats, after which behavior and pathology\u00a0were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>DSP\u20104 compromised LC cell bodies, fibers, and NE content. LC lesion and the AD transgene each affected several affective behaviors and\/or cognition individually, but few interactions were found, and DSP\u20104 failed to exacerbate behavioral phenotypes or neuropathology in TgF344\u2010AD rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Combined with previous literature, our data suggest that LC lesions exacerbate pre\u2010existing AD\u2010like pathology and behavioral impairments, rather than accelerate their onset. Further characterization of LC lesions in TgF344\u2010AD rats at different ages is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71334","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:12:23Z","timestamp":1775542343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of early locus coeruleus lesions in the TgF344 Alzheimer's disease rat model"],"prefix":"10.1002","volume":"22","author":[{"given":"Alexia E.","family":"Marriott","sequence":"first","affiliation":[{"name":"Department of Human Genetics Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P.","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Emory University  Atlanta Georgia 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