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AD\/ADRD diagnoses were identified via International Classification of Diseases (ICD) codes \u22656 months post\u2010baseline. Cox models and cumulative incidence functions (CIFs) adjusted for demographic and clinical variables, with death as a competing risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Higher NLR was associated significantly with increased AD\/ADRD risk in both cohorts (NYU hazard ratio [HR]\u00a0=\u00a01.07, 95% confidence interval [CI] 1.02\u20131.15; VA HR\u00a0=\u00a01.21, 95% CI 1.10\u20131.34). Spline analysis further confirmed a continuous dose\u2013response relationship, and subgroup analyses showed higher risk among female and Hispanic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Elevated NLR is independently associated with higher AD\/ADRD risk across diverse populations, highlighting the role of systemic inflammation and neutrophil\u2010mediated pathways in neurodegeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71335","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:10:42Z","timestamp":1775211042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neutrophil inflammation metrics are associated with the risk of future dementia in large data from NYU Langone Hospitals and the Veterans Health Administration"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9752-1256","authenticated-orcid":false,"given":"Tianshe","family":"He","sequence":"first","affiliation":[{"name":"VA Boston Cooperative Studies Program, MAVERIC VA Boston Healthcare System  Boston Massachusetts USA"},{"name":"Department of Psychiatry New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Betensky","sequence":"additional","affiliation":[{"name":"Department of Biostatistics NYU School of Global Public Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo S.","family":"Osorio","sequence":"additional","affiliation":[{"name":"Department of Psychiatry New York University Grossman School of Medicine  New York New York USA"},{"name":"Nathan Kline Institute Orangeburg  New York 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