{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:15Z","timestamp":1783322175633,"version":"3.54.6"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>This study evaluates plasma\u2010based proteomic profiles for predicting amyloid positivity in adults with Down syndrome (DS) and examines the impact of apolipoprotein E \u03b54 (APOE \u03b54) on test performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Cross\u2010sectional data from 290 adults with DS were analyzed using single molecule array (SIMOA) technology to measure plasma amyloid beta (A\u03b2)42, A\u03b240, neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), tau phosphorylated at threonine 181, and total tau. Amyloid burden was quantified using Pittsburgh Compound B\u00a0and (18)F\u2010florbetapir A\u03b2 positron emission tomography. Support vector machine analyses were conducted with biomarkers as predictors and age, sex, and APOE \u03b54 carrier status as covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Age, GFAP, and NfL contributed the most to the model performance. The proteomic profile achieved an area under the curve (AUC) of 96% in models with and without APOE \u03b54.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings suggest that plasma proteomic biomarkers can effectively identify amyloid positivity in adults with DS and may support clinical triage, monitoring, and selection for clinical trials, independent of APOE \u03b54 status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71338","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T09:32:08Z","timestamp":1775899928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The association between APOE \ud835\udf004 carrierships and the detection of amyloid positivity using an Alzheimer's disease proteomic blood test in asymptomatic Down syndrome"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-1075","authenticated-orcid":false,"given":"Lubnaa Badriyyah","family":"Abdullah","sequence":"first","affiliation":[{"name":"Department of Family Medicine UNT Health Fort Worth  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine UNT Health Fort Worth  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine UNT Health Fort Worth  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Family Medicine UNT Health Fort Worth  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Handen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mapstone","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Christian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California, Irvine, School of Medicine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Head","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California, Irvine, School of Medicine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigan","family":"Harley","sequence":"additional","affiliation":[{"name":"University of Wisconsin Madison, Waisman Center  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Neurology New York Columbia University, Vagelos College of Physicians and Surgeons, Taub Institute for Research on Alzheimer's Disease and the Aging Brain  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology New York Columbia University, Vagelos College of Physicians and Surgeons, Taub Institute for Research on Alzheimer's Disease and the Aging Brain  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Tudorascu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California, Irvine, School of Medicine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy","family":"Hom","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior University of California, Irvine (UCI) School of Medicine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Zaman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Clinical Medicine University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M","family":"Brickman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior University of California, Irvine (UCI) School of Medicine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Rosas","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Radiology Harvard Medical School, Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California, Irvine, School of Medicine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan P","family":"Harp","sequence":"additional","affiliation":[{"name":"Kentucky Neuroscience Institute &amp; Sanders\u2010Brown Center on Aging University of Kentucky College of Medicine  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California, Irvine, School of Medicine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Ptomey","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Burns","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira T","family":"Lott","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California, Irvine, School of Medicine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Laymon","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cruchaga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sid","family":"O'Bryant","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beau M.","family":"Ances","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00245-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430316"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3983"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(88)90041-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.05.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12023"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14068"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201167"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-101335"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.1740"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac333"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02408-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00129-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30285-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24319-x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188802"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00593-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.03.015"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00158"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14359"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab223"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12039"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190322"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.1893"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2039"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400518"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.1996.0003"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.1893"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.11.001"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13444"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00408-2"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12065"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.1997.tb00692.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.2000.00264.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201167"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.06.004"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2018.12.008"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14068"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaf406"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v028.i05"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2019.04.006"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12447"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4986"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00070-3"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01657-3"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-00967-z"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14442"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70446"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70135"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00604-9"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30689-9"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00129-0"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.10.006"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.10.001"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa326"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.05.016"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12113"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-00977-5"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71338","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:52:13Z","timestamp":1783320733000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/alz.71338"],"URL":"https:\/\/doi.org\/10.1002\/alz.71338","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71338"}}