{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:26Z","timestamp":1783322186688,"version":"3.54.6"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Blood pressure (BP) trajectories are associated with dementia, but their relevance across neurodegenerative and metabolic backgrounds in hypertensive populations remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 28,135 hypertensive participants from the China Rural Hypertension Control Project to estimate BP trajectories over 4 years using latent class group\u2010based models. A nested case\u2013control study was designed to assess interaction effects between BP trajectories and pTau217\u2010lipid composite indices on dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Four BP trajectories\u00a0were identified. In fully adjusted models, the high\u2010stable diastolic BP trajectory showed the strongest association with dementia\u00a0(odds ratio [OR]\u00a0=\u00a02.14, 95% confidence interval [CI] 1.74\u20132.63), followed by high\u2010stable systolic BP trajectory (OR\u00a0=\u00a01.75, 95% CI 1.42\u20132.15). In the nested case\u2010control analysis, significant interactions between pTau217\u2010lipid composite indices and BP trajectories (high\u2010declining and moderate\u2010stable) were observed in relation to dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>High\u2010stable BP trajectories were consistently associated with dementia, whereas the associations between high\u2010declining and moderate\u2010stable BP trajectories varied according to pTau217\u2010lipid composite indices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71346","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:09:32Z","timestamp":1775542172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal blood pressure trajectories and tau\u2010lipid biomarkers associated with dementia in hypertensive adults: Results from the population\u2010based CRHCP cohort"],"prefix":"10.1002","volume":"22","author":[{"given":"Shanshan","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Neurology The First Hospital of China Medical University  Shenyang Liaoning China"},{"name":"Key Laboratory of Neurological Disease Big Data of Liaoning Province  Shenyang Liaoning China"},{"name":"Shenyang Clinical Medical Research Center for Difficult and Serious Diseases of the Nervous System  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanxiang","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of China Medical 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