{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:23Z","timestamp":1783322183286,"version":"3.54.6"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"am","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG072978"],"award-info":[{"award-number":["P30AG072978"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG083735"],"award-info":[{"award-number":["R01AG083735"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["HT9425\u201024\u20101\u20101046"],"award-info":[{"award-number":["HT9425\u201024\u20101\u20101046"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Repetitive head impacts (RHI) from contact sports may cause a unique pattern of white matter hyperintensities (WMH) on T2\u2010weighted fluid\u2010attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), termed RHI\u2010associated WMH (RHI\u2010WMH). These lesions are punctate, circular, and located at the gray\u2013white matter boundary, an area vulnerable to trauma\u2010related damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We investigated the association of RHI with these lesions in two aging cohorts: (1) former American football players versus asymptomatic unexposed men and (2) individuals with RHI from various contact sports versus non\u2010RHI participants. RHI\u2010WMH were assessed using visual ratings and a novel automated quantification pipeline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Individuals with RHI had greater RHI\u2010WMH by both detection methods in both cohorts. RHI\u2010WMH were associated with plasma neurofilament light and p\u2010tau231, and flortaucipir positron emission tomography (PET) uptake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>RHI\u2010WMH may represent a new supportive biomarker for the detection of RHI\u2010related neuropathologies later in life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71351","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T03:20:04Z","timestamp":1776655204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imaging the later\u2010life white matter pathologies of repetitive head impacts: A novel pattern revealed through T2 FLAIR MRI"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-9314","authenticated-orcid":false,"given":"Jenna R.","family":"Groh","sequence":"first","affiliation":[{"name":"Department of Neurology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Boston University Alzheimer's Disease Research Center and BU CTE Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalise E.","family":"Miner","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Boston University Alzheimer's Disease Research Center and BU CTE Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad J.","family":"Alshikho","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Farris","sequence":"additional","affiliation":[{"name":"Boston University Alzheimer's Disease Research Center and BU CTE Center  Boston Massachusetts USA"},{"name":"Department of Radiology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Department of Radiology Boston Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Boston University Alzheimer's Disease Research Center and BU CTE Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Pettway","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Boston University Alzheimer's Disease Research Center and BU CTE Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Labonte","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Boston University Alzheimer's Disease Research Center and BU CTE Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Mosaheb","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Boston University Alzheimer's Disease Research Center and BU CTE Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorghos","family":"Tripodis","sequence":"additional","affiliation":[{"name":"Boston University Alzheimer's Disease Research Center and BU CTE Center  Boston Massachusetts USA"},{"name":"Department of Biostatistics Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Arizona  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Balcer","sequence":"additional","affiliation":[{"name":"Department of Neurology NYU Grossman School of Medicine  New York New York USA"},{"name":"Department of Population Health and Ophthalmology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Bernick","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lou Ruvo Center for Brain Health  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Cantu","sequence":"additional","affiliation":[{"name":"Boston University Alzheimer's Disease Research Center and BU CTE Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry Mass General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Dodick","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Arizona  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas 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Institute and Arizona Alzheimer's Consortium  Phoenix Arizona USA"},{"name":"Translational Genomics Research Institute  Phoenix Arizona USA"},{"name":"Department of Psychiatry University of Arizona  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha E.","family":"Shenton","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry Mass General Hospital  Boston Massachusetts USA"},{"name":"Department of Radiology Mass General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Stern","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Boston University Alzheimer's Disease Research Center and BU CTE Center  Boston Massachusetts USA"},{"name":"Department of Anatomy &amp; Neurobiology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Department of Neurosurgery Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C.","family":"McKee","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Boston University Alzheimer's Disease Research Center and BU CTE Center  Boston Massachusetts USA"},{"name":"Department of Pathology and Laboratory Medicine Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"VA Boston Healthcare System, U.S. Department of Veteran Affairs  Jamaica Plain Massachusetts USA"},{"name":"U.S. Department of Veteran Affairs VA Bedford Healthcare System  Bedford Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor 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