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These genes, spanning multiple proteostasis pathways, were differentially expressed in microtubule associated protein tau\n                      <jats:italic>(MAPT)<\/jats:italic>\n                      mutant neurons and dysregulated in FTD and AD brains.\n                      <jats:italic>NINL<\/jats:italic>\n                      , which encodes Nlp, emerged as the only gene consistently upregulated across all datasets.\n                      <jats:italic>NINL<\/jats:italic>\n                      overexpression reduced tau seeding and enhanced lysosomal proteolytic activity, whereas two FTD\u2010enriched\n                      <jats:italic>NINL<\/jats:italic>\n                      frame shift variants impaired Nlp expression and abolished these protective effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      We identified a set of proteostasis genes with genetic and transcriptional links to neurodegeneration and revealed\n                      <jats:italic>NINL<\/jats:italic>\n                      as a novel regulator of tau aggregation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71352","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:01:45Z","timestamp":1775728905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrative genomic and functional analyses reveal\n                    <i>NINL<\/i>\n                    as a modulator of tau aggregation"],"prefix":"10.1002","volume":"22","author":[{"given":"Samantha K.","family":"Swift","sequence":"first","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"},{"name":"The Charles F. and Joanne Knight Alzheimer Disease Research Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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