{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:25Z","timestamp":1783322185659,"version":"3.54.6"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG054070"],"award-info":[{"award-number":["R01AG054070"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF\u201021\u2010848200"],"award-info":[{"award-number":["AARF\u201021\u2010848200"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Parental history of dementia is associated with increased dementia risk. We investigated whether having a parent with dementia is associated with increased peripheral inflammation in middle\u2010aged adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Participants were from the Offspring Study (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01204). Parental dementia status was determined by a diagnostic consensus conference. Plasma chemokine and cytokine concentrations were assayed with Luminex technology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Parental history of dementia was associated with higher levels of eotaxin and lower levels of granulocyte colony\u2010stimulating factor, vascular endothelial growth factor A, and interleukin (IL)\u201027. IL\u201018 and epidermal growth factor levels were higher in Black individuals with a parental history of dementia compared to Hispanic individuals with the same history. Women with a parental history of dementia had higher levels of interferon\u2010alpha 2, IL\u201012p70, soluble CD40 ligand, and IL\u201018 compared to men with the same history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Parental history of dementia is associated with elevated markers of peripheral inflammation. These associations vary across sex, race, and ethnicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71355","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:52:27Z","timestamp":1776059547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between parental history of dementia and plasma markers of inflammation in a multi\u2010ethnic middle\u2010aged community of adults"],"prefix":"10.1002","volume":"22","author":[{"given":"Edric D.","family":"Winford","sequence":"first","affiliation":[{"name":"Department of Neurology Taub Institute for Research on Alzheimer's Disease and the Aging Brain Gertrude H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Neurology Taub Institute for Research on Alzheimer's Disease and the Aging Brain Gertrude H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Seblova","sequence":"additional","affiliation":[{"name":"Department of Public Health Second Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Pyne","sequence":"additional","affiliation":[{"name":"Department of Neurology Taub Institute for Research on Alzheimer's Disease and the Aging Brain Gertrude H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justina F.","family":"Avila\u2010Rieger","sequence":"additional","affiliation":[{"name":"Department of Neurology Taub Institute for Research on Alzheimer's Disease and the Aging Brain Gertrude H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira C.","family":"Turney","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences National Institute on Aging National Institutes of Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Mazen","sequence":"additional","affiliation":[{"name":"Department of Neurology Taub Institute for Research on Alzheimer's Disease and the Aging Brain Gertrude H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[{"name":"Department of Neurology Taub Institute for Research on Alzheimer's Disease and the Aging Brain Gertrude H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9481-7497","authenticated-orcid":false,"given":"Jennifer J.","family":"Manly","sequence":"additional","affiliation":[{"name":"Department of Neurology Taub Institute for Research on Alzheimer's Disease and the Aging Brain Gertrude H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00627-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-319148"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316201"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls187"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00229"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-01975-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12399"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000132679.92238.58"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.5.565"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007231"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.1763"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70683-X"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018101064"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10357"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13457"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.06.2360"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3063"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2025.03.019"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16187"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbaa027"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/pnasnexus\/pgac219"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.02.019"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2020.53.1.309"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.12.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2022.11.009"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-86309-z"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/1047322X.1990.10389587"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666171123201142"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.01.021"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01696"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.6.893"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.9.2.136"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(18)30622-6"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01259-6"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.131"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-020-00201-3"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341780"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062481"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1653"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00285-8"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00775.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.06.031"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-013-0405-4"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160477"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.336134"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-021-01802-0"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.10.001"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2020.110945"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e41725"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12675"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713083"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000536082"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.986840"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.949340"},{"key":"e_1_2_8_58_1","first-page":"2088","article-title":"TLR7 ligands induce higher IFN\u2010alpha production in females","volume":"177","author":"Bergh\u00f6fer B","year":"2006","journal-title":"J Immunol Baltim Md 1950"},{"key":"e_1_2_8_59_1","first-page":"5444","article-title":"X\u2010Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7\u2010mediated IFN\u2010\u03b1 production of plasmacytoid dendritic cells from women","volume":"193","author":"Laffont S","year":"2014","journal-title":"J Immunol Baltim Md 1950"},{"key":"e_1_2_8_60_1","first-page":"5327","article-title":"Sex differences in plasmacytoid dendritic cell levels of IRF5 drive higher IFN\u2010\u03b1 production in women","volume":"195","author":"Griesbeck M","year":"2015","journal-title":"J Immunol Baltim Md 1950"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010065X.2009.00782.x"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152710791012099"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031114"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-020-00256-1"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107700"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-00816-2"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.1800066"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170277"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.011"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13926"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71355","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:57:16Z","timestamp":1783321036000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/alz.71355"],"URL":"https:\/\/doi.org\/10.1002\/alz.71355","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71355"}}