{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:58:45Z","timestamp":1787961525395,"version":"build-2784847793"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U24AG088894"],"award-info":[{"award-number":["U24AG088894"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Government policies targeting key risk factors for cognitive decline are potential levers for preventing or delaying dementia. Policy is therefore a central component of the exposome\u2014the cumulative exposures shaping dementia risk across the life course. While extensive research links individual risk factors to dementia, less attention has been paid to how public policies structure these risks. We introduce the concept of the\n                    <jats:italic>policy exposome<\/jats:italic>\n                    and summarize findings from a structured expert consultation conducted by the Gateway Exposome Coordinating center (GECC) to identify priority policy research domains. We argue that systematic collection and harmonization of policy data across countries and sub\u2010national regions can enable causal research on dementia. We propose a tiered research framework to guide policy data collection, prioritizing education, tobacco and alcohol control, air pollution, and old\u2010age social assistance. Using tobacco control as a case study, we illustrate how policies can be operationalized as exposures linkable to dementia outcomes.\n                  <\/jats:p>","DOI":"10.1002\/alz.71362","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T09:09:16Z","timestamp":1776157756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The policy exposome of dementia: Gaps, opportunities, and research agenda"],"prefix":"10.1002","volume":"22","author":[{"given":"Cl\u00e9mence","family":"Kieny","sequence":"first","affiliation":[{"name":"Center for Primary Care and Public Health (Unisant\u00e9) Department of Epidemiology and Health Systems University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"Marks","sequence":"additional","affiliation":[{"name":"Center for Primary Care and Public Health (Unisant\u00e9) Department of Epidemiology and Health Systems University of Lausanne  Lausanne Switzerland"},{"name":"Institute of Health Law University of Neuch\u00e2tel  Neuch\u00e2tel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheo","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"Center for Primary Care and Public Health (Unisant\u00e9) Department of Epidemiology and Health Systems University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Survana","family":"Alladi","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neurosciences (NIMHANS)  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Atshan","sequence":"additional","affiliation":[{"name":"Center for Economic and Social Research University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Brayne","sequence":"additional","affiliation":[{"name":"Cambridge Public Health University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Dow","sequence":"additional","affiliation":[{"name":"School of Public Health University of California  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Glymour","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Knapp","sequence":"additional","affiliation":[{"name":"Center for Economic and Social Research University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gill","family":"Livingston","sequence":"additional","affiliation":[{"name":"Division of Psychiatry University College London  London UK"},{"name":"Camden and Islington NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhaj","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Economic Research and Development Impact Department Asian Development Bank  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Monnet","sequence":"additional","affiliation":[{"name":"Center for Primary Care and Public Health (Unisant\u00e9) Department of Epidemiology and Health Systems University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Papanicolas","sequence":"additional","affiliation":[{"name":"Department of Health Services Policy and Practice Center for Health System Sustainability Brown University School of Public Health  Providence Rhode Island USA"},{"name":"Department of Health Policy London School of Economics  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Platt","sequence":"additional","affiliation":[{"name":"Center for Public Health Law Research Temple University Beasley School of Law  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rehkopf","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Stanford University School of Medicine  Stanford California USA"},{"name":"Center for Population Health Sciences Stanford University School of Medicine  Stanford California USA"},{"name":"Department of Health Policy Stanford University School of Medicine  Stanford California USA"},{"name":"Department of Medicine Stanford University School of Medicine  Stanford California USA"},{"name":"Department of Pediatrics Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Sadana","sequence":"additional","affiliation":[{"name":"Ageing and Health Unit Department of Maternal, Newborn, Child and Adolescent Health and Ageing WHO  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Community Health and Epidemiology Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Walsh","sequence":"additional","affiliation":[{"name":"Cambridge Public Health University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McKayla","family":"Wenner","sequence":"additional","affiliation":[{"name":"Center for Economic and Social Research University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Avendano","sequence":"additional","affiliation":[{"name":"Center for Primary Care and Public Health (Unisant\u00e9) Department of Epidemiology and Health Systems University of Lausanne  Lausanne Switzerland"},{"name":"Department of Social and Behavioral Sciences Harvard T.H. Chan School of Public Health  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(21)00249\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12901"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.57"},{"key":"e_1_2_9_5_1","volume-title":"The Strategy of Preventive Medicine","author":"Rose G","year":"1992"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(23)02068\u20108"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(24)01296\u20100"},{"key":"e_1_2_9_8_1","volume-title":"Risk reduction of cognitive decline and dementia: WHO guidelines","author":"Organization WH","year":"2019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr236"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1215\/03616878-3665931"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30235-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20100009.2010.00595.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwae468"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHH.0000000000001833"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2008.49.720"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000007036"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.219"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-0297.2012.02499.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwaa255"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm116"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.17132"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.22341"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010023\u201003972\u20105"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010018\u20100453\u20100"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010025\u201000844\u2010y"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2666\u20107568(22)00004\u20106"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/17437199.2025.2508987"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780195377903.003.0006"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02545-8"},{"issue":"5","key":"e_1_2_9_30_1","first-page":"247","article-title":"Intensive blood pressure lowering prevents mild cognitive impairment and possible dementia and slows development of white matter lesions in brain: the SPRINT memory and cognition IN decreased hypertension (SPRINT MIND) study","volume":"27","author":"Kjeldsen SE","year":"2018","journal-title":"Taylor & Francis"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100944"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.37247"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.4427"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4249"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70039"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1201"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1586\/erp.11.70"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.23690"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1212623"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.1080566"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.15276"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab130"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10081277"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003015"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.9297"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11414-019-09660-w"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjc.12259"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.14316"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14387"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2023.107669"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000901"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2025.1658101"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.06.1885"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30403-4"},{"key":"e_1_2_9_55_1","volume-title":"A blueprint for dementia research","author":"World Health Organization","year":"2022"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:58:10Z","timestamp":1783321090000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/alz.71362"],"URL":"https:\/\/doi.org\/10.1002\/alz.71362","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71362"}}