{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:33Z","timestamp":1783322193664,"version":"3.54.6"},"reference-count":70,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The locus coeruleus is among the earliest brain regions affected by tau pathology in Alzheimer's disease (AD), but the functional impact is difficult to measure in vivo. Task\u2010evoked pupil dilation provides an index of locus coeruleus\u2013norepinephrine function that might be altered in cognitively normal older adults with underlying AD pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Cognitively normal older adults identified as AD biomarker positive (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a025) or negative (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a036) based on plasma phosphorylated tau (p\u2010tau) levels completed a conjunctive visual search task that manipulated attentional load by varying set size. Pupil dilation responses during the task were analyzed using mixed\u2010effects models and time\u2010resolved regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Despite comparable accuracy and reaction times, biomarker\u2010positive adults showed reduced load\u2010dependent modulation of pupil dilation during target\u2010present trials. Weaker modulation was associated with higher p\u2010tau levels and poorer executive and memory function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Attenuated task\u2010evoked modulation of pupil dilation during visual search reveals locus coeruleus\u2013norepinephrine dysfunction in preclinical AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71363","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:29:03Z","timestamp":1776439743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Attenuated pupillary response during visual search in preclinical Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3700-4270","authenticated-orcid":false,"given":"Elena K.","family":"Festa","sequence":"first","affiliation":[{"name":"Department of Cognitive and Psychological Sciences Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Heindel","sequence":"additional","affiliation":[{"name":"Department of Cognitive and Psychological Sciences Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille A.","family":"Marangi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"},{"name":"UCSD Shiley\u2010Marcos Alzheimer's Disease Research Center  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britney","family":"Escobedo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"},{"name":"UCSD Shiley\u2010Marcos Alzheimer's Disease Research Center  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Galasko","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"},{"name":"UCSD Shiley\u2010Marcos Alzheimer's Disease Research Center  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Salmon","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"},{"name":"UCSD Shiley\u2010Marcos Alzheimer's Disease Research Center  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zou","sequence":"additional","affiliation":[{"name":"UCSD Shiley\u2010Marcos Alzheimer's Disease Research Center  La Jolla California USA"},{"name":"Herbert Wertheim School of Public Health and Human 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