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Ferroptosis, a mechanism of cell death, may be influenced by dietary interventions. Ferroptosis is driven by labile iron generating reactive oxygen species, resulting in lipid peroxidation and cellular death. Iron accumulates in the brain in various neurodegenerative disorders, and this correlates with disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We reviewed studies reporting effects of dietary interventions on brain iron accumulation and\/or ferroptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We report indications that dietary interventions can impact ferroptosis in the brain. Anti\u2010ferroptotic effects involve reduced lipid peroxidation, enhanced antioxidant defense activity, and reduced labile iron through altered iron metabolism. Transcription factor\n                      <jats:italic>Nrf2<\/jats:italic>\n                      may be the core regulator of dietary anti\u2010ferroptotic effects, connecting the three pathways of ferroptosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Targeting ferroptosis through diet may offer a feasible approach to supporting brain health across neurodegenerative conditions, but dedicated studies are required to directly investigate this potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71368","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T15:11:37Z","timestamp":1777302697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferroptotic neurodegeneration and diet: a narrative review"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2609-4597","authenticated-orcid":false,"given":"Ximaine R.","family":"van der Burg","sequence":"first","affiliation":[{"name":"C. 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Gorter MRI Center Department of Radiology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Ayton","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health  Melbourne Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanno","family":"Pijl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"van der Weerd","sequence":"additional","affiliation":[{"name":"C. J. Gorter MRI Center Department of Radiology Leiden University Medical Center  Leiden the Netherlands"},{"name":"Department of Human Genetics Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Dementia. Updated 31 March 2025. 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