{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:20:19Z","timestamp":1785151219037,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>National Veterans Affairs electronic health records were used to examine the association between traumatic brain injury (TBI) severity and four dementia phenotypes ranging from narrow (strict AD) to broad (all\u2010cause dementia).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Veterans with TBI (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a091,753) and a propensity score\u2010matched comparison group of veterans without TBI (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0183,506) were included. Four validated dementia phenotypes defined using International Classification of Diseases (ICD) codes were evaluated. The association between TBI severity and each dementia phenotype was examined using adjusted logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>TBI severity was significantly associated with increased odds of developing dementia across the three broader dementia phenotypes in a dose\u2013response manner (moderate\/severe\/penetrating TBI\u00a0&gt;\u00a0mild TBI). Those with unclassified TBI had disease risk falling in between mild and more severe TBI. In contrast, TBI was associated with decreased risk of strict AD across all severity levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Findings support a dose\u2013response relationship between TBI severity and broader dementia risk but raise questions regarding the TBI\u2013AD link.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71370","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:06:23Z","timestamp":1777100783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential associations between traumatic brain injury severity and four dementia phenotypes in military veterans"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5683-4168","authenticated-orcid":false,"given":"Victoria C.","family":"Merritt","sequence":"first","affiliation":[{"name":"Research Service VA San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry School of Medicine University of California San Diego  La Jolla California USA"},{"name":"Center of Excellence for Stress and Mental Health (CESAMH) VA San Diego Healthcare System  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Valocchi","sequence":"additional","affiliation":[{"name":"Research Service VA San Diego Healthcare System  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca V.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Research Service VA San Diego Healthcare System  San Diego California USA"},{"name":"Department of Psychiatry School of Medicine University of California San Diego  La Jolla California USA"},{"name":"Center of Excellence for Stress and Mental Health 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