{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:41Z","timestamp":1783322201659,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ALZSI\u201025\u20101464205"],"award-info":[{"award-number":["ALZSI\u201025\u20101464205"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG\u201025\u20101485687"],"award-info":[{"award-number":["AARG\u201025\u20101485687"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["24HPE\u20101287320"],"award-info":[{"award-number":["24HPE\u20101287320"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Biological, genetic, and sociocultural factors underlying cognitive resilience and resistance to pathology remain unexplored in Latin America. The Life\u2010Course Epidemiology of Aging, Resilience, and Neurodegeneration in Alzheimer's Disease (LEARN\u2010AD) study and Latin American SuperAgers Study (LASAS) establish the first harmonized frameworks to characterize resilience and exceptional cognitive aging phenotypes in the region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The shared protocol integrates cognitive, neurological, psychosocial, and genetic data. SuperAgers are deeply phenotyped, while successful cognitive agers are identified through harmonized criteria applied to existing cohorts, ensuring regional adaptation and international comparability. Centralized training and shared procedures ensure cross\u2010site consistency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We define eligibility criteria and standardized assessments to classify successful cognitive agers and SuperAgers in Latin America and examine biological and psychosocial profiles supporting better\u2010than\u2010expected cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>LEARN\u2010AD and LASAS represent the first Latin American infrastructure for studying cognitive resilience, resistance, and exceptional cognitive aging, which will generate unprecedented regional databases and grow into larger networks, providing foundations for research, prevention strategies, and precision approaches to promote brain health in Latin America.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71373","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T09:05:42Z","timestamp":1776157542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A harmonized framework for studying exceptional cognitive aging in Latin America"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0083-9389","authenticated-orcid":false,"given":"Lucia","family":"Crivelli","sequence":"first","affiliation":[{"name":"Departamento de Neurolog\u00eda Cognitiva Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurociencias de la Memoria Instituto de Fisiolog\u00eda, Biolog\u00eda Molecular y Neurociencias (IFIByNE, CONICET)  Buenos Aires Argentina"},{"name":"Facultad 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Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel","family":"Surace","sequence":"additional","affiliation":[{"name":"Laboratorio de Enfermedades Neurodegenerativas (LEN)\u2010 Instituto de Neurociencias Fleni\u2010CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issac","family":"Acosta","sequence":"additional","affiliation":[{"name":"Laboratory of the Dementias National Institute of Neurology and Neurosurgery  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Caramelli","sequence":"additional","affiliation":[{"name":"Behavioral and Cognitive Neurology Unit Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Aguill\u00f3n","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia Facultad de Medicina Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javiera Leniz","family":"Martelli","sequence":"additional","affiliation":[{"name":"School of Public Health Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissette Duque","family":"Pe\u00f1ailillo","sequence":"additional","affiliation":[{"name":"Unidad de Trastornos Cognitivos Neuromedicenter  Quito Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilton","family":"Custodio","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n de Deterioro Cognitivo y Prevenci\u00f3n de Demencia, Instituto Peruano de Neurociencias  Lince Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Charamelo","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de la Memoria\u2010Hospital Brit\u00e1nico  Montevideo 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