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We characterized sleep alterations in cognitively unimpaired older adults with cerebral amyloid deposition, and assessed their associations with regional amyloid deposition and cognitive and psychoaffective outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Seventy\u2010six older adults (69.1\u00a0\u00b1\u00a03.4 years, 63.2% female) underwent a multi\u2010night (4.5\u00a0\u00b1\u00a00.8 nights) objective sleep assessment using the Somno\u2010Art wearable device, Florbetapir\u2010positron emission tomography (PET) scanning, and an extensive neuropsychological and psychoaffective evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Amyloid \u03b2 (A\u03b2)\u2010positive individuals had a shorter total sleep time (TST) and greater night\u2010to\u2010night variability in rapid eye movement (REM) sleep duration than A\u03b2\u2010negative individuals. Across the whole sample, these sleep characteristics were associated with increased A\u03b2 deposition in widespread brain regions, but not with cognitive or psychoaffective measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Shorter sleep duration and greater REM sleep variability may index early AD\u2010related brain changes, warranting longitudinal studies to establish their prognostic significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:bold>Trial Registration<\/jats:bold>\n                      : Age\u2010Well randomized clinical trial of the Medit\u2010Ageing European Project. Trial registration number: EudraCT:2016\u2010002,441\u201036; IDRCB:2016\u2010A01767\u201044; ClinicalTrials.gov Identifier: NCT02977819\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71376","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:35:44Z","timestamp":1776440144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Night\u2010to\u2010night rapid eye movement sleep variability: A relevant marker of early amyloid\u2010\u03b2 deposition"],"prefix":"10.1002","volume":"22","author":[{"given":"Blandine","family":"Montagne","sequence":"first","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, UA20, Neuropresage, GIP Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00e9va","family":"Boulin","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, UA20, Neuropresage, GIP 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