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Cell transplantation effects were assessed by\u00a0behavioral analysis, electrophysiology, immunofluorescence staining, immunoblotting, and RNA sequencing analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>MGE\u2010pIN integration restored local inhibition, correcting E:I imbalance and\u00a0suppressing\u00a0electroencephalogram (EEG)\u2010detected epileptiform discharges. This network recovery, underpinned by normalized receptor subunit levels and restored synaptic plasticity \u2013 as evidenced by long\u2010term potentiation recordings, morphological analysis, and transcriptomic profiling \u2013 led to the rescue of cognitive deficits. Importantly, these functional benefits occurred\u00a0independently of\u00a0amyloid beta levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The study's findings suggest that targeted interneuron replacement can reverse network dysregulation and cognitive decline in AD, underscoring the potential of cell\u2010based modulation as a route to restore brain function in neurodegenerative disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71378","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T15:18:53Z","timestamp":1777303133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Human iPSC\u2010derived GABAergic interneuron transplantation restores circuit balance and cognitive function in an Alzheimer's disease model"],"prefix":"10.1002","volume":"22","author":[{"given":"Xinzhe","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital (PUMCH) Peking Union Medical College (PUMC) &amp; Chinese Academy of Medical Science(CAMS)  Beijing China"},{"name":"Mckusick\u2010Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences PUMC &amp; CAMS  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaojie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital (PUMCH) Peking Union Medical College (PUMC) &amp; Chinese Academy of Medical Science(CAMS)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital (PUMCH) Peking Union Medical College (PUMC) &amp; Chinese Academy of Medical Science(CAMS)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital (PUMCH) Peking Union Medical College (PUMC) &amp; Chinese Academy of Medical Science(CAMS)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziteng","family":"Wangliu","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital (PUMCH) Peking Union Medical College (PUMC) &amp; Chinese Academy of Medical Science(CAMS)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital (PUMCH) Peking Union Medical College (PUMC) &amp; Chinese Academy of Medical Science(CAMS)  Beijing 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