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We investigated whether baseline brain MRI findings associate with pre\u2010frailty\/frailty over 11 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>One hundred twenty participants, aged 60 to 77 years, in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) had baseline MRI data. Frailty status (Fried phenotype) was measured at baseline, and at 2, 7, and 11 years. Risk of future pre\u2010frailty\/frailty per one standard deviation or one class greater volume\/thickness\/Fazekas score in baseline MRI was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Pre\u2010frailty\/frailty was not associated with MRI biomarkers at baseline. Smaller left hippocampal volume was associated with pre\u2010frailty\/frailty at 2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.042) and 7 years (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017), and higher load of periventricular white matter hyperintensities (WMHs) at 2 years (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.048), independently of baseline cognition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Smaller left hippocampal volume and higher periventricular WMH score in brain MRI may indicate future frailty risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:bold>Clinical Trial Registration number<\/jats:bold>\n                      : The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is registered at ClinicalTrials.gov (no. NCT01041989)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71379","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:11:12Z","timestamp":1776222672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain magnetic resonance imaging biomarkers for future frailty; sub\u2010study of FINGER trial"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1524-6134","authenticated-orcid":false,"given":"Johanna","family":"P\u00f6yh\u00f6nen","sequence":"first","affiliation":[{"name":"Department of Public Health Finnish Institute for Health and Welfare (THL)  Helsinki Finland"},{"name":"Department of Medicine, Clinicum University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna\u2010Maria","family":"Roitto","sequence":"additional","affiliation":[{"name":"Department 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Medicine, Clinicum University of Helsinki  Helsinki Finland"},{"name":"Department of Geriatrics Helsinki University Hospital  Helsinki Finland"},{"name":"Center for Life Course Health Research\/Geriatrics University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miia","family":"Kivipelto","sequence":"additional","affiliation":[{"name":"Department of Public Health Finnish Institute for Health and Welfare (THL)  Helsinki Finland"},{"name":"Division of Clinical Geriatrics, Center for Alzheimer Research Care Sciences and Society (NVS), Karolinska Institutet  Stockholm Sweden"},{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland  Kuopio Finland"},{"name":"Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London  London UK"},{"name":"Theme Inflammation and Aging Karolinska University Hospital  Stockholm 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