{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:45Z","timestamp":1783322205694,"version":"3.54.6"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100023581","name":"National Science Foundation Graduate Research Fellowship Program","doi-asserted-by":"publisher","award":["DGE\u20102137420"],"award-info":[{"award-number":["DGE\u20102137420"]}],"id":[{"id":"10.13039\/100023581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Life course models of Alzheimer's disease (AD) suggest that both long\u2010term exposure to neighborhood conditions and changes in neighborhood context may shape dementia risk. This study examined the impact of mid\u2010 and late\u2010life levels of neighborhood segregation, as well as longitudinal change in segregation, on plasma AD biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Participants were 119 racially\/ethnically diverse (60% Black\/Latino) adults. Residential addresses were geocoded to temporally harmonized US Census tracts, and the dissimilarity index quantified segregation. Plasma neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and amyloid beta (A\u03b2) 42\/40 were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Generalized estimating equations adjusting for individual\u2010level sociodemographic and health characteristics revealed mid\u2010life, but not late\u2010life, levels of segregation were significantly associated with NfL. Increasing segregation across 10\u2010 and 20\u2010year periods was associated with higher levels of GFAP and NfL, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Mid\u2010life levels of segregation and longitudinal change in segregation were linked to plasma markers of neurodegeneration and astroglial activation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71382","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:23:03Z","timestamp":1777040583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Life course neighborhood conditions and change: a 20\u2010year examination of neighborhood context and associations with Alzheimer's disease biomarkers in late life"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-5409","authenticated-orcid":false,"given":"Alexandra L.","family":"Clark","sequence":"first","affiliation":[{"name":"Department of Psychology The University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbey M.","family":"Hamlin","sequence":"additional","affiliation":[{"name":"Department of Psychology The University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000518\u20107"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7559"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.18865\/ed.25.3.245"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207566"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(05)70286\u20106"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.2.285"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12702"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12385"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bsa3.70014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2019.305001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jes.2016.10"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1154515"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11524\u2010019\u201000400\u20101"},{"key":"e_1_2_8_15_1","unstructured":"WayHK MuellerE WegmannJ Uprooted: Residential Displacement in Austin's Gentrifying Neighborhoods and What Can Be Done About It.2018. 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