{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:48Z","timestamp":1783322208686,"version":"3.54.6"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Migraine and dementia are prevalent disorders with high societal impact; however, research regarding their association remains inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 6888 participants from the prospective Rotterdam Study. Migraine status was assessed (2006\u20132011) via validated questionnaire. Participants were followed for a median of 9.4 years until January 2020. Dementia diagnoses were confirmed through in\u2010person screenings and medical record linkages, including neuroimaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>At baseline, 1041 participants (15.1%) had migraine. Over 62,180 person\u2010years, 491 participants developed dementia (379 [77.2%] with Alzheimer's). Cox models revealed that migraine was associated with a lower risk of dementia (hazard ratio [HR] 0.70, 95% confidence interval [CI]: 0.51\u20130.95) and Alzheimer's disease (HR 0.58, 95% CI: 0.40\u20130.85).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This study suggests that migraine is associated with a reduced risk of dementia, including Alzheimer's disease. Whether this reflects biological neuroprotection or methodological factors is currently unclear, necessitating further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71386","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T03:34:15Z","timestamp":1777001655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Migraine and the Risk of Dementia in the General Population"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1991-916X","authenticated-orcid":false,"given":"Cevdet","family":"Acarsoy","sequence":"first","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-2603","authenticated-orcid":false,"given":"Daniel","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-2944","authenticated-orcid":false,"given":"Sanne S.","family":"Mooldijk","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0372-8585","authenticated-orcid":false,"given":"M. Arfan","family":"Ikram","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0173-9571","authenticated-orcid":false,"given":"M. Kamran","family":"Ikram","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Neurology Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010025\u201002078\u20100"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010018\u20100925\u20104"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010023\u201007069\u20100"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.804341"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520\u2010021\u201002065\u2010w"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010020\u201000640\u20105"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20102982.2003.00824.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.53.3.537"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024221132008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010015\u20100377\u20105"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001270050095"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0446-4_6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017719"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.359"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30367\u20106"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527320666210713114840"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194\u2010011\u20100321\u20109"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010015\u20100385\u20102"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916\u2010021\u201000976\u2010x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14039"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51516"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194\u2010008\u20100006\u20101"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2021.03.018"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102017\u2010020498"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40211\u2010018\u20100299\u20105"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102017\u2010316274"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13613"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.613372"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102017\u2010019399"},{"key":"e_1_2_8_32_1","volume-title":"IBM SPSS Statistics for Windows, Version 25.0","year":"2017"},{"key":"e_1_2_8_33_1","volume-title":"R: A language and environment for statistical computing","year":"2020"},{"key":"e_1_2_8_34_1","volume-title":"A package for survival analysis in R","year":"2022"},{"key":"e_1_2_8_35_1","volume-title":"ggplot2: Elegant graphics for data analysis","year":"2016"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2009.01411.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414552531"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13066"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419843148"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024241266951"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417708774"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13214"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010019\u20100132\u20106"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.07.014"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12774"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2012.02265.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010020\u201001166\u20107"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911418"}],"container-title":["Alzheimer's &amp; 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