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Analysis of covariance and Cox models tested associations between dulaglutide, SCI, and plasma neurofilament light chain (NfL), phosphorylated tau217 (p\u2010tau217), and glial fibrillary acidic protein (GFAP) biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Dulaglutide\u2010associated changes in biomarkers or SCI were nonsignificant overall.\u00a0Participants with NfL \u226556 pg\/mL had a dulaglutide\u2010associated 2\u2010year reduction in NfL (\u221227.4% vs \u221214.2%;\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.003). Participants with p\u2010tau217 \u226525\u00a0pg\/mL had a dulaglutide\u2010associated SCI reduction (hazard ratio\u00a0=\u00a00.78;\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.0064).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Dulaglutide reduced NfL and SCI in participants with select elevated plasma ADRD biomarkers, with limited 2\u2010year effects on p\u2010tau217 and GFAP. Future studies with longer follow\u2010up should explore incretin\u2010related cognitive changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIAL REGISTRATION INFORMATION<\/jats:title>\n                    <jats:p>NCT01394952, registered July 15, 2011.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71391","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:18:52Z","timestamp":1776334732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dulaglutide and neurodegeneration biomarkers: REWIND post hoc analysis"],"prefix":"10.1002","volume":"22","author":[{"given":"Jonathan M.","family":"Wilson","sequence":"first","affiliation":[{"name":"Eli Lilly and Company, Lilly Corporate Center  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Dage","sequence":"additional","affiliation":[{"name":"Stark Neurosciences Research Institute Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Rong","family":"Qian","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Lilly Corporate Center  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney L.","family":"Irelan","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Lilly Corporate Center  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah S.","family":"Crowder","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Lilly Corporate Center  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Duffin","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Lilly Corporate Center  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mintun","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Lilly Corporate Center  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn A.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Lilly Corporate Center  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hertzel C.","family":"Gerstein","sequence":"additional","affiliation":[{"name":"Population Health Research Institute  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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