{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:00:39Z","timestamp":1785477639009,"version":"3.56.0"},"reference-count":68,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The relationship between peripheral vascular health, including endothelia, cognitive decline, and Alzheimer's disease (AD) dementia risk is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this study, 2844 dementia\u2010free Framingham Offspring participants (mean age 60.6 years, 53.2% women) had baseline brachial artery flow\u2010mediated dilation (FMD%) and reactive hyperemia (RH). Participants were then followed for a median of 17 years for incident AD and underwent plasma biomarker testing and brain magnetic resonance imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      FMD% (hazard ratio [HR]\u00a0=\u00a00.83, 95% confidence interval [CI] 0.76 to 0.91,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and RH (HR\u00a0=\u00a00.89, 95% CI 0.79 to 0.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.049) were negatively associated with incident AD dementia after adjusting for confounders. Associations were stronger in individuals with elevated C\u2010reactive protein. Poor vascular function correlated with higher plasma AD biomarkers, smaller brain volumes, greater white matter injury, and increased cerebral microbleeds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Poor FMD% and RH may serve as a prognostic biomarker for cerebrovascular pathology, including endothelial dysfunction in the AD brain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71396","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:34:31Z","timestamp":1777433671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peripheral vascular function, including endothelium\u2010dependent measures, and dementia risk: The Framingham Heart 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