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However, current use recommendations preclude the administration of these new drugs to persons who have Down syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This narrative review considers the ethical and biological factors relating to the administration of anti\u2013amyloid\u2010\u03b2 monoclonal antibody therapies to persons who have Down syndrome. Literature was selected based on relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Here, we discuss the current understanding of Down syndrome Alzheimer's disease, and how this informs potential benefits and risks of treatment with anti\u2013amyloid\u2010\u03b2 monoclonal antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The blood\u2013brain barrier and immune system differ in persons with Down syndrome, and cerebral amyloid angiopathy is elevated compared to late\u2010onset Alzheimer's disease. Thus, side\u2010effect risks from anti\u2013amyloid\u2010\u03b2 monoclonal antibodies are likely to be elevated. 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