{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:40Z","timestamp":1783322200998,"version":"3.54.6"},"reference-count":76,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016599","name":"Purdue Institute for Drug Discovery","doi-asserted-by":"publisher","award":["2006929"],"award-info":[{"award-number":["2006929"]}],"id":[{"id":"10.13039\/100016599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016599","name":"Purdue Institute for Drug Discovery","doi-asserted-by":"publisher","award":["1715202"],"award-info":[{"award-number":["1715202"]}],"id":[{"id":"10.13039\/100016599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The genetic and clinical factors influencing the rate of brain structure change in cognitive decline remain poorly understood. This study aimed to identify genetic variants and risk factors contributing to these changes and explore potential causal relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed data from 2036 individuals across three longitudinal cohorts to assess change rates in 17 brain regions associated with cognitive decline. Genome\u2010wide association studies (GWASs) were followed by phenome\u2010wide association studies (PheWASs), Mendelian randomization (MR), and independent replication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We identified loci associated with brain structure change, including known Alzheimer's disease genes (apolipoprotein E,\n                      <jats:italic>APOC1<\/jats:italic>\n                      ) and novel signals (\n                      <jats:italic>BEAN1<\/jats:italic>\n                      ,\n                      <jats:italic>SDHC<\/jats:italic>\n                      ). PheWAS and MR analyses in large biobanks suggested potential causal links between brain atrophy and anemia\u2010related traits as well as type 2 diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings highlight genetic contributors and clinical traits associated with brain structure change in cognitive decline. Larger studies with broader cognitive assessments are needed to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71411","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:28:28Z","timestamp":1776745708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors underlying brain structure change rate in cognitive decline: Results from genomewide and phenomewide investigations"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-7677","authenticated-orcid":false,"given":"Yin","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Purdue University  West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolia","family":"Topaloudi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Purdue 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