{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T11:14:56Z","timestamp":1783250096917,"version":"3.54.6"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG051142"],"award-info":[{"award-number":["R01AG051142"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG009740"],"award-info":[{"award-number":["U01AG009740"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The exposome encompasses all environmental exposures across the life course, yet educational environments, a critical socioenvironmental exposure, remain underexplored despite their role in cognitive aging and Alzheimer's disease and related dementias (AD\/ADRD). Traditional measures, such as years of schooling, underestimate exposure heterogeneity and mechanisms influencing cognitive reserve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The Educational Exposome Framework integrates psychosocial, resource\u2010based, environmental, and structural domains of education: academic self\u2010efficacy, home and community learning resources, and institutional learning contexts drawing on life\u2010course, exposomic, and cognitive health research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The framework conceptualizes education as a multidimensional, interacting system shaping cognitive development, stress biology, and neurodegeneration. Legacy and emerging datasets, including High School &amp; Beyond, Health and Retirement Study, and Add Health, enable life\u2010course reconstruction of educational exposures linked to midlife and later\u2010life cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>By capturing mechanistic pathways and leveraging linked data, the framework supports equity\u2010focused dementia prevention and clarifies education's role in AD\/ADRD risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71413","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:00:53Z","timestamp":1781175653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Educational Exposome: A life\u2010course socioenvironmental framework for advancing Alzheimer's disease and ADRD 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